SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulation of these seemingly different roles is coordinated. Here, we show that SHARPIN binds integrin ...

Zanxiang Nie 1,2,*, Xi Xiao 1,*, Pritesh Hiralal 3, Xuanrui Huang 1, Richard McMahon 4, Min Zhang 5 and Weijia Yuan 5 1 Department of Electrical Engineering, Tsinghua University, Beijing 100084, China; [email protected] 2 Zinergy Shenzhen Ltd., Taohuayuan Science and Technology Innovation Park, Baoan, Shenzhen 518101, China 3 Zinergy UK Ltd., Future Businesss Centre, Cambridge CB4 2HY, UK; prite...

Christopher F. H. Nam, John A. D. Aston, Idris A. Eckley, Rebecca Killick Department of Statistics, University of Warwick, Coventry, CV4 7AL, UK Statistical Laboratory, DPMMS, University of Cambridge, Cambridge, CB3 0WB, UK Department of Mathematics and Statistics, University of Lancaster, Lancaster, LA1 4YF, UK {c.f.h.nam | j.a.d.aston }@warwick.ac.uk {i.eckley | r.killick }@lancaster.ac.uk Fe...

Facial pruritus associated with spinal opiate analgesia in man is thought to result either from release of histamine or from imbalance of sensory modulation secondary to spread of opiate to the medulla or fourth ventricle. There is another possibility: the sensory imbalance may be secondary to rostral spread of opiate effect by nervous transmission. Evidence is adduced in support of possible an...

We describe an unusual case of a 12-year-old boy who presented with a loss of motion in the ring finger caused by 2 separate periosteal chondromas involving the proximal and middle phalanges. Range of motion improved and recurrence did not occur at the 5-year follow-up after marginal excision of both lesions.

In order for China to play a bigger, more positive role in the world, it is important for China to have a healthy capital market. This perception motivates us to examine the health of China's capital market, especially the severity of the overall loss of the listed companies in China and the effects of accounting irregularities on the losses. We show the overall loss of the listed companies was...