Coating shrinkage upon drying is a phenomenon well known to the paper coating industry where it often causes changes in the final structure of the coating layer, leading to poor results in terms of gloss, light scattering, surface strength, coverage and printability. The aim of this paper is to improve the understanding of coating shrinkage by measuring the forces related to the capillarity, ac...

Subcellular membraneless assemblies are a reinvigorated area of study in biology, with spirited scientific discussions on the forces between the low-complexity protein domains within these assemblies. To illuminate these forces, we determined the atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies. Their common structural feature is the...

Ab initio molecular dynamics (AIMD) is still one of the most commonly used approaches for calculating the time evolution of molecular and solid state systems under ambient conditions of temperature and pressure. Specifically, AIMD is particularly suited for the simulation of complex molecular systems that undergo important reorganizations of their electronic structure (bond breaking and bond fo...

The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected or transformed target cell is a physically active structure capable of exerting mechanical force. Here, we investigated whether synaptic forces promote the destruction of target cells. CTLs kill by secreting toxic proteases and the pore forming protein perforin into the synapse. Biophysical experiments revea...

I use high resolution N-body/SPH simulations to model the new proper motion of the Large Magellanic Cloud (LMC) within the Milky Way (MW) halo and investigate the effects of gravitational and hydrodynamical forces on the formation of the Magellanic Stream (MS). Both the LMC and the MW are fully self consistent galaxy models embedded in extended cuspy ΛCDM dark matter halos. I find that ram-pres...

Cell-cell adhesions are important sites through which cells experience and resist forces. In endothelial cells, these forces regulate junction dynamics and determine endothelial barrier strength. We identify the Ig superfamily member EMMPRIN (also known as basigin) as a coordinator of forces at endothelial junctions. EMMPRIN localization at junctions correlates with endothelial junction strengt...

This study stemmed from the observation that the brain of human as well as nonhuman primates is capable of forming and memorizing remarkably accurate internal representations of the dynamics of the arm. These dynamics establish a functional relation between applied force and ensuing arm motion, a relation that generally is quite complex and nonlinear. Current evidence shows that the motor contr...

Although there is good experimental evidence for the Aharonov Bohm phase shift occurring when a solenoid is placed between the beams forming a double-slit electron interference pattern, there has been very little analysis of the relevant classical electromagnetic forces. These forces between a point charge and a solenoid involve subtle relativistic effects of order v c analogous to those discus...

The bending of cilia and flagella is driven by forces generated by dynein motor proteins. These forces slide adjacent microtubule doublets within the axoneme, the motile cytoskeletal structure. To create regular, oscillatory beating patterns, the activities of the axonemal dyneins must be coordinated both spatially and temporally. It is thought that coordination is mediated by stresses or strai...

Platelets play an important role in hemostasis by forming a thrombotic plug that seals the vessel wall and promotes vascular healing. After platelets adhere and aggregate at the wound site, their next step is to generate contractile forces through the coordination of physicochemical interactions between actin, myosin, and alpha(IIb)beta(3) integrin receptors that retract the thrombus' size and ...