Background Early and accurate diagnosis of fatal familial insomnia (FFI) is critical for effective screening; however, this rare disease remains difficult to recognize. This work aimed propose a new diagnostic criterion with optimal sensitivity, specificity, likelihood ratio. Methods An international group experts was established 128 genetically confirmed FFI cases 281 non-FFI prion controls ar...

Content and Language Integrated Learning (CLIL) has recently been the focus of numerous studies in language education since it aims to overcome the pitfalls of form-focused and meaning-focused instruction by systematically integrating content and language. This meta-analysis aims to synthesize the findings of 22 primary studies that tested the effect of CLIL on language skills and components. G...

Cerebellar feedforward inhibition (FFI) is mediated by two distinct pathways targeting different subcellular compartments of Purkinje cells (PCs). The axon of the granule cell, the parallel fiber, makes excitatory synapses not only onto PCs but also onto two types of interneurons, basket and stellate cells. Basket and stellate cells then send inhibitory signals to the soma and dendrites of Purk...

In L2 development, the cognitive complexity of tasks plays a crucial role in task performance and language features produced. However, there have only been few studies addressing the impact of task complexity on EFL learners' attention to L2 system and form-focused self-repairs (FFS).This study explores the role of increasing cognitive task complexity in EFL learners' form-focused attention (FF...

The current study examines the impact of different task types on learning prepositions in form and meaning- focused interaction enhancement- based classes. The participants were 57 second Year University students enrolled in three intact lab classes at Tabriz Islamic Azad University.  The first group was provided with form-focused interaction enhancement, the second with the meaning-focused int...

this study was inspired by vanpatten and uludag’s (2011) study on the transferability of training via processing instruction to output tasks and mori’s (2002) work on the development of talk-in-interaction during a group task. an interview was devised as the pretest, posttest, and delayed posttest to compare four intervention types for teaching the simple past passive: traditional intervention ...

A great deal of research focuses on how humans and animals learn from trial-and-error interactions with the environment. This research has established the viability of reinforcement learning as a model of behavioral adaptation and neural reward valuation. Error-driven learning is inefficient and dangerous, however. Fortunately, humans learn from nonexperiential sources of information as well. I...

Neurons receive a large number of excitatory and inhibitory synaptic inputs whose temporal interplay determines the spiking behavior. On average, excitation and inhibition balance each other, such that spikes are elicited by fluctuations [1]. In addition, it has been shown in vivo that excitation and inhibition are correlated, with inhibition lagging excitation only by few milliseconds (∼6 ms),...

Hepatic fatty infiltration generally appears in a widespread form but it can occasionally involve the liver in an irregular way. As regards focal forms, nodular focal fatty infiltration (NFFI) has great importance regarding problems of differential diagnosis with benign and malignant focal pathology of the liver. Except for this aspect, NFFI has little clinical importance as it is mainly asympt...

FFI, a rare prion disease, constitutes by their wake and sleep abnormalities a unique pathophysiological model of disease. Recently, a neurobiological-mathematical model of the human sleep/ wake cycle (MMSWC) developed by Rempe, BestJ and Terman, reconciles circadian/homeostatic influences with new findings like the proposed sleep/wake flip-flop switch and REM-NoREM switch. We attempt now to mo...