Four randomised, placebo-controlled trials have previously documented the clinical benefits of azithromycin (AZM) in cystic fibrosis (CF) patients. The present study examined whether the beneficial effect of AZM is equivalent when administered daily or weekly. A double-blind, randomised study was carried out in 208 CF patients aged 6-58 yrs who were assigned to AZM either 250 mg daily (n = 103)...

OBJECTIVE Positive effects of growth hormone therapy on growth, nutritional status, and lung function have been observed in patients with cystic fibrosis, but the current evidence is based on unblinded studies that involved a small number of patients. This trial was designed as a multicenter, randomized, placebo-controlled, double-blind study to assess the efficacy and safety of 2 dosages of gr...

We wanted to evaluate the improvement in efficacy when increasing the daily dose of inhaled steroids and to compare the efficacy, safety, and tolerance of 1.6 mg beclomethasone dipropionate (BDP) with that of 2.0 mg fluticasone propionate (FP). The study was a randomized, double-blind, 3 month, multicentre study. One hundred and thirty four asthmatics currently using inhaled steroids (0.4-1.6 m...

Expression of the constitutive Hsp73, inducible Hsp72 and Hsp90 was investigated in brain, heart, liver and skeletal muscle of the anoxia-tolerant western painted turtle Chrysemys picta bellii in response to 2, 6, 12, 18, 24 and 30 h forced dives and following 1 h recovery from 12, 24 and 30 h forced dives at 17 degrees C. During a dive, expression of all three Hsps examined remained at control...

background: various variance reduction techniques such as forced detection (fd) have been implemented in monte carlo (mc) simulation of nuclear medicine in an effort to decrease the simulation time while keeping accuracy. however most of these techniques still result in very long mc simulation times for being implemented into routine use. materials and methods: convolution-based forced detectio...

background the forced oscillation technique (fot) is a non-invasive means of measuring respiratory resistance and reactance. we tested our hypothesis that endotracheal intubation would cause more substantial preoperative increases in fot parameters than a supraglottic airway device (sgd). methods forty patients requiring general anesthesia and mechanical ventilation for transurethral bladder tu...

‎a numerical technique based on the collocation method using legendre multiwavelets are‎‎presented for the solution of forced duffing equation‎. ‎the operational matrix of integration for‎‎legendre multiwavelets is presented and is utilized to reduce the solution of duffing equation‎‎to the solution of linear algebraic equations‎. ‎illustrative examples are included to demonstrate‎‎the validity...

objective(s): in this study the effect of crocin, a carotenoid isolated from saffron, on malathion (an organophosphate insecticide) induced depressive- like behavior in subacute exposure was investigated. moreover the molecular mechanism of malathion induced depressive- like behavior and its decreasing effect on the level of brain derived neurotrophic factor (bdnf) in rat hippocampus and cerebr...

OBJECTIVE To investigate the relation between ventilatory function and subsequent mortality due to cerebrovascular disease. DESIGN Prospective longitudinal study. SUBJECTS A total of 18,403 male civil servants aged 40-64 years at entry examination for the Whitehall study. MAIN OUTCOME MEASURE Mortality from cerebrovascular disease (ICD8 430-438) after 18 years of follow up. RESULTS In a...

Anergy is a state of immunologic tolerance in which T cells are viable but incapable of responding to antigenic stimulation. Recent data indicate that anergic cells have a distinct gene expression program that determines their unique function. In this study we show that anergic human T cells selectively express the small GTPase ADP-ribosylation factor-6 (ARF6), which is involved in membrane tra...