The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) wa...

Two insect growth regulators, methoprene and a benzyl-1,3,benzodioxole (J-2931), had no detrimental effects on Dugesia tigrina under field conditions. Three other compounds, resmethrin, temephos, and cyromazine, had only minimal effects. Asexual multiplication among these planarian predators exceeded 68% when combined with Culex quinquefasciatus larvae and methoprene at different concentration ...

We present the Wrst study of the eVects of ocean acidiWcation on settlement of benthic invertebrates and microfauna. ArtiWcial collectors were placed for 1 month along pH gradients at CO2 vents oV Ischia (Tyrrhenian Sea, Italy). Seventy-nine taxa were identiWed from six main taxonomic groups (foraminiferans, nematodes, polychaetes, molluscs, crustaceans and chaetognaths). Calcareous foraminifer...

Planarians have been used as a model to study development and regeneration for more than 200 years. Research on these animals has traditionally focused on surgical and pharmacological manipulations. Recently, the dissection of planarians has become more molecular in nature. The isolation of thousands of expressed sequence tags and the introduction of in situ hybridizations, immunocytology, and ...

Mutations in Deleted in Azoospermia (DAZ), a Y chromosome gene, are an important cause of human male infertility. DAZ is found exclusively in primates, limiting functional studies of this gene to its homologs: boule, required for meiotic progression of germ cells in invertebrate model systems, and Daz-like (Dazl), required for early germ cell maintenance in vertebrates. Dazl is believed to have...

the satellite cells. Contaminating CD45+/Mac-1+/Sca-1+ cells were subsequently removed by MACS cell separation. Cell cycle analysis revealed that over 80% of the resulting myogenic cell population was in G0, indicating a high proportion of quiescent cells in the isolated population. RT-PCR analysis showed that the expression of three Kruppel-like factors (Klf) was increased in quiescent satelli...

Since its first announcement by P. Sensi et at. in 19591}, the rifamycin complex has been extensively studied by a number of workers2). The type culture Nocardia mediterranea (Margalith et Beretta) Thiemann et at. 1969*, then known as Streptomyces mediterranei^ was isolated from a soil sample collected in France. Sugawara et al.l) culturing an isolate (4107 A2) from a Japanese soil sample, repo...