units for the synthesis of the purine ring and the methylation of uridylate to thymidylate is a fundamental requirement for cell replication. The mammalian cell cannot synthesize the basic pteroylglutamate structure and, consequently, growth and maturation of both normal and neoplastic cells require an exogenous source of this vitamin. For this reason, the folate coenzymes have been the target ...

been stripped of most of their proteins, the pericentriolar material can be seen to consist of a fibrous core, to which other proteins and complexes are attached. Mi-crotubule nucleation is accomplished by the ␥-tubulin Stanford, California 94305 complex, a large ring-shaped multiprotein complex that localizes to the pericentriolar material and provides a template for the addition of tubulin su...

The implementation of thyroid hormone (T3) or glucagon as lipid-lowering, antidiabetic, and antiobesity agents have not been successful to date because of serious adverse side effects. Using a synthetic hybrid glucagon/T3 conjugate, Finan et al have established a novel therapeutic approach for the reversal of dyslipidemia, obesity, and insulin resistance associated with the metabolic syndrome, ...