Here we show that interruption of the VCAM-1/VLA-4 axis with a small molecule inhibitor of VLA-4, BIO5192, results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels. An additive affect on HSPC mobilization (3-fold) was observed when plerixafor (AMD3100), a small molecule inhibitor of the CXCR-4/SDF-1 axis, was combined with BIO5192. Fur...

The energy required for mechanical inhibition of target proteases is stored in the native structure of inhibitory serpins and accessed by serpin structural remodeling. The overall serpin fold is ellipsoidal with one long and two short axes. Most of the structural remodeling required for function occurs along the long axis, while expansion of the short axes is associated with misfolded, inactive...

GaInN/GaN multiple quantum well light-emitting diode structures in polar c-axis and non-polar m-axis growth have been compared in terms of luminescence properties. Grown under identical conditions, under low excitation density the c-axis structure has a luminescence maximum at 558nmwhile the maxis structure shows a maximum at 488nm and shows superluminescence at 485nm under high photoexcitation...

objective(s) the mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (hpa) axis remain elusive. the endocannabinoid system (ecbs) which exhibits antidepressant potential, appears to regulate the hpa axis activity. therefore, we aimed to investigate the role of the ecbs in the action of doxepin including its effect on the hpa axis. materials and methods male wistar ...

There has been increasing interest in functional heterogeneity along the septotemporal, dorsal-ventral (D-V) axis of the hippocampus. Although anatomical connectivity and lesion studies point to discrete roles for these sub-regions, the contribution of differential gene expression across this axis has not been systematically studied. Here we present findings from an Affymetrix microarray screen...

The two mass model (2MM) as introduced by Ishizaka & Flanagan (1972) and simplified by Steinecke & Herzel (1995) describes many features of the vocal fold oscillation patterns [1,2]. Particularly, it was shown that a large variety of voice disorders may be explained by means of high-speed observations with subsequent interpretation by the 2MM. Laryngeal symmetry was identified as an important p...