نتایج جستجو برای: foam cells
تعداد نتایج: 1396021 فیلتر نتایج به سال:
Oxidative Modification of LDL Although LDL is essential to deliver cholesterol to tissues, increased LDL cholesterol is associated with increased risk of cardiovascular disease. Oxidative modification of LDL promotes recruitment and retention of monocytes3 with formation of fatty streaks, the earliest lesions in atherosclerosis.4 Both macrophages and vascular smooth muscle cells (VSMCs) bind ox...
The concept that macrophages can become foam cells as a result of a disturbed balance between the uptake of cholesterol from lipoproteins and cholesterol efflux is generally accepted. ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently their combined role in vivo is unknown. We report here that targeted disruption of both ABCA...
cular Cell Adhesion Molecule-1 (VCAM-1), mediating a more sustained leukocyte adhesion to the endothelium. Chemokines attract monocytes and lymphocytes to the area allowing for their subsequent interaction with the endothelial adhesion molecules. Monocytes migrate between the endothelial cells and in response to a variety of chemical factors, mature into macrophages and express “scavenger recep...
OBJECTIVE Various cell adhesion molecules are expressed in atherogenesis and the significance of their involvement in atherosclerotic lesion formation is well appreciated. In the present work, we examined whether the Ca(2+)-dependent cell adhesion molecule E-cadherin is also involved in atherogenesis. METHODS Specimens of carotid artery and aorta were obtained at operation. Expression of E-ca...
in many processes polymeric foams can be produced by using chemical or physical blowing agents. in this work for polyethylene foam production, the chemical blowing agents and compression moulding process were employed. at first, by using dsc diagram of two polyethylene grades, a suitable polyethylene grade was selected for foam production and then we discuss about blowing agent critical percent...
Cultured rabbit aortic smooth muscle cells were converted to foam cells by exposure to sonicated lipid droplets of defined composition using an inverted culture technique. Uptake of the lipid droplets by the cells was shown to be dependent on the time of exposure to the droplets and on the mass of droplets presented to the cells. A comparison of the hydrolysis of triolein and cholesteryl oleate...
Coronary artery disease, resulting from atherosclerosis, is the leading cause of death in the Western world. Most previous studies have subjected atherosclerotic arteries, a tissue of mixed cellular composition, to homogenization in order to identify the factors in plaque development, thereby obscuring information relevant to specific cell types. Because macrophage foam cells are critical media...
background: holothuroids (sea cucumbers) are members of the phylum echinodermata, which produce saponins. saponins exhibit a wide spectrum of pharmacological and biological activities. in this study, we isolated the crude saponins from the body wall of the dominant iranian species of sea cucumber, holothuria leucospilota (h. leucospilota). the purpose of this study was to confirm the presence o...
Macrophage-derived foam cells express apolipoprotein E (apoE) abundantly in atherosclerotic lesions. To examine the physiologic role of apoE secretion by the macrophage in atherogenesis, bone marrow transplantation was used to reconstitute C57BL/6 mice with macrophages that were either null or wild type for the apoE gene. After 13 weeks on an atherogenic diet, C57BL/6 mice reconstituted with ap...
MafB is a transcription factor that induces myelomonocytic differentiation. However, the precise role of MafB in the pathogenic function of macrophages has never been clarified. Here we demonstrate that MafB promotes hyperlipidemic atherosclerosis by suppressing foam-cell apoptosis. Our data show that MafB is predominantly expressed in foam cells found within atherosclerotic lesions, where MafB...
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