نتایج جستجو برای: fndc5

تعداد نتایج: 325  

2014
Brian A. Irving Christopher D. Still George Argyropoulos

The epidemic of obesity has contributed to the rapid rise in comorbid conditions such as cardiovascular disease, type 2 diabetes, sleep apnea, and hypertension among others. Therefore, there is a critical need to develop therapeutic strategies to reduce the prevalence of the disease. Skeletal muscle cells secrete signaling cytokines/peptides (referred to as myokines) that act in autocrine, para...

2017
Lakshminarasimhan Sundarrajan Chanel Yeung Logan Hahn Lynn P Weber Suraj Unniappan

Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha). We aimed to study the role of irisin on cardiac function and muscle protein regulation in zebrafish. Western blot analyses det...

2015
Luis Gamas Paulo Matafome Raquel Seiça

Myokines are peptides produced and secreted by the skeletal muscle, with autocrine, paracrine, and endocrine actions. Many of them are overexpressed during physical exercise and appear to contribute to the benefits of exercise to metabolic homeostasis. Irisin, resulting from the cleavage of the membrane protein FNDC5, was shown to induce adipocyte browning, with increased lipid oxidation and th...

Journal: :Annals of the New York Academy of Sciences 2017
Graziana Colaianni Saverio Cinti Silvia Colucci Maria Grano

Irisin is a hormone-like myokine produced in abundance by skeletal muscle in response to exercise, both in mice and humans. Once released into the circulation, irisin acts on white adipocytes to induce the browning response and subsequently activates nonshivering thermogenesis. We have examined the premise that irisin produced during exercise may subserve further functions in the musculoskeleta...

Journal: :Clinical endocrinology 2014
Rocio de la Iglesia Patricia Lopez-Legarrea Ana B Crujeiras Maria Pardo Felipe F Casanueva Maria A Zulet Jose A Martinez

OBJECTIVE A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of patients with metabolic syndrome (MetS) following a hypocaloric diet. DESIGN Ninety-three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8-week-long energy-restricted programme (-30% of...

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