The removal of ionisable drugs (fluoxetine, sulfamethizole and antipyrine) from aqueous solution was performed by conventional adsorption using carbonaceous aerogel pellets as adsorbents. Although >96 % elimination achieved for antipyrine after 1440 min, only 2.5 fluoxetine removed. In a multicomponent system, the presence these three in leads to fivefold depletion adsorbed total mass. Thus, au...

Objective: The objective of this study is to assess the pharmacokinetics changes of carvedilol when given with a known CYP2D6 inhibitor like fluoxetine. Background: Carvedilol is β-blockers with vasodilating activity, and it is first β-blocker approved by the Food and Drug Administration (FDA) as adjunctive therapy in the treatment of chronic heart failure (CHF). Carvedilol is extensively metab...

vitamin b6 is a cofactor of various enzymes influencing numerous neurotransmitters in the brain such as norepinephrin, and serotonin . since these neurotransmitters influence mood , the aim the present work to evaluate the effect of vitamin b6 on depression and obsessive compulsive behavior when coadministred with clomipramine, fluoxetine, or venlafaxine. male mice weighing 25-30 g were used. t...

fluoxetine, a widely used antidepressant, can affect the serum sodium level. the aim of this study was to evaluate and compare changes in the serum sodium level of depressive patients taking fluoxetine according to age.this quasi-experimental study was conducted on 126 patients with depression, dividing the patients into two age groups of 15 to 35 years, and above 55 years, who referred to psyc...

serotonin specific reuptake inhibitors (ssri) may induce antinociception however, the mechanism of this effect is not clear. ssrls increase 5-ht levels in neuronal synapses and facilitate serotonergic activity. in this study, therefore, the activity of para-chlorophenylalanine (pcpa), which reduces 5-ht release, and 5- hydroxy tryptophan (5-htp), a precursor of 5-ht, were examined on the antino...

BACKGROUND: Anxiety disorder is one of the most common psychiatric problems. Prolonged stress gives rise to anxiety-like behavior in animals. Environmental interventions influence outcome anxiety treatment. enrichment (EE) can modulate brain’s structure and function. AIM: The objective study was evaluate EE effects on corticosterone (CORT) level after unpredictable chronic mild (UCMS). METHODS:...

objectives: fluoxetine is a selective serotonin re-uptake inhibitor (ssri) widely used for depression, bipolar disorder, anxiety and obsessive-compulsive disorder. the aim of this study was to assess the effect of fluoxetine on orthodontic tooth movement (otm) in rats. materials and methods: forty-five male wistar rats were randomly divided into three groups namely the control group (no medicat...

conclusions it was concluded that the efficacy of tramadol and fluoxetine in males with premature ejaculation are the same and both are effective. both of these drugs are safe to treat premature ejaculation. results thirty-six subjects with the mean age of 44 ± 19.3 years underwent analysis. eighteen subjects were treated by fluoxetine and 18 by tramadol. the efficacy of treatment in the two gr...

The antidepressant fluoxetine induces synaptic plasticity in the visual and fear networks and promotes the structural remodeling of neuronal circuits, which is critical for experience-dependent plasticity in response to an environmental stimulus. We recently demonstrated that chronic fluoxetine administration together with extinction training in adult mice reduced fear in a context-independent ...