Fluorination became the more radical approach for modification of leading compounds in medicinal chemistry [1,2]. Due to its small size and high electronegativity, fluorine forms a strong covalent bond with carbon, shows a significant impact on neighboring groups that alter the stability and reactivity of the molecules, helps to creates more stable protein folds [3,4]. Fluorinated amino acids w...

An omega-fluorine-labeled oxyethylene thiol ligand, F(CH2CH2O)2CH2CH2SH, was synthesized, characterized and incorporated into mixed self-assembled monolayers with CH3(OCH2CH2)3SH onto a planar gold substrate and onto 2 nm gold nanoclusters. The fluorine-labeled nanocluster was self-assembled onto gold substrates using alkane dithiol (HS(CH2)nSH; n = 5, 8, 11) and oxyethylene dithiol (HS(CH2CH2O...

A comprehensive study is made of the behavior and effects of fluorine in n-polysilicon layers. The polysilicon is deposited in a conventional low pressure chemical vapor deposition furnace on ~100! silicon wafers, implanted with 1310 cm F and 1310 cm As and annealed at 850, 950, 1015, and 1065 °C. Sheet resistance, transmission electron microscopy ~TEM!, and secondary ion mass spectroscopy are ...

Intensive investigations during the last years have shown that metabotropic glutamate receptors are involved in numerous neurodegenerative diseases such as M. Parkinson, M. Alzheimer and M. Huntington as well as other central nervous system disorders including neurogenic pain, epilepsy, depression and drug addiction. The neurobiological basis of these impairments is, however, still not well und...

Because of their specific properties, vegetal fibers are increasingly used as sustainable polymer reinforcements for eco-composites. Nevertheless, polar character hinders them from being more frequently at industrial scale due to incompatibility with mostly dispersive polymers (the cheapest and most common ones). In this study, direct fluorination treatment was carried out covalently graft fluo...

The accumulation of marine biological growth has irreversible negative effects on shipping and coastal fisheries. In this paper, a new antibacterial nanofiller—triazole fluoroaromatic hydrocarbon?modified nano?zinc oxide (ZnO?APTES?TRF)—was prepared by Cu(I)?catalyzed azide–alkyne click chemical reaction. modification nano?ZnO with triazole ring hydrocarbons were testified FT?IR, XPS, EDS. graf...

An efficient route to substituted 1-aryl-1H-indazoles has been developed and optimized. The method involved the preparation of arylhydrazones from acetophenone or benzaldehyde substituted by fluorine at C2 and nitro at C5, followed by deprotonation and nucleophilic aromatic substitution (SNAr) ring closure in 45-90%. Modification of this procedure to a one-pot domino process was successful in t...

Hydrophobic Y-zeolite (SiO2/Al2O3 = 810) and TiO2 composite photocatalysts were designed by using two different types of TiO2 precursors, i.e., titanium ammonium oxalate and ammonium hexafluorotitanate. The porous structure, surface property and state of TiO2 were investigated by various characterization techniques. By using an ammonium hexafluorotitanate as a precursor, hydrophobic modificatio...