BACKGROUND AND PURPOSE Computational fluid dynamics has become a popular tool for studying intracranial aneurysm hemodynamics, demonstrating success for retrospectively discriminating rupture status; however, recent highly refined simulations suggest potential deficiencies in solution strategies normally used in the aneurysm computational fluid dynamics literature. The purpose of the present st...

– We study the steady-state response to applied stress in a simple scalar model of sheared colloids. Our model is based on a schematic (F2) model of the glass transition, with a memory term that depends on both stress and shear rate. For suitable parameters, we find transitions from a fluid to a nonergodic, jammed state, showing zero flow rate in an interval of applied stress. Although the jamm...

We investigate granular transport by a fluid flow under steady-state driving conditions, from the bed-load regime to the suspension regime, with an experimental system based on a conical rheometer. The mean granular volume fraction φg , the mean granular velocity ug , and the fluid velocity uf are obtained as a function of depth inside the bed using refractive index matching and particle-tracki...

BACKGROUND Glioma cells are exposed to elevated interstitial fluid flow during the onset of angiogenesis, at the tumor periphery while invading normal parenchyma, within white matter tracts, and during vascular normalization therapy. Glioma cell lines that have been exposed to fluid flow forces in vivo have much lower invasive potentials than in vitro cell motility assays without flow would ind...

A Mathematical model for the pulsatile blood flow through stenosed artery with the effect of body acceleration and slip velocity is proposed. Blood has been represented by casson fluid equation. Analytic expression for velocity, flow rate, wall shear stress and effective viscosity is derived. Flow variables with the change of parameters are represented graphically. The effect of pulsatility, st...

The binding of plasma von Willebrand factor (VWF) to platelet receptor GpIb under high hydrodynamic shear leads to platelet activation and subsequent shearinduced platelet aggregation (SIPA). We quantitatively examined the aspects of fluid flow that regulate platelet activation by subjecting human blood and isolated platelets to well-defined shear conditions in a cone-plate viscometer. We made ...

In this study, a realistic model for dynamic instability of embedded single-walled nanotubes (SWCNTs) conveying pulsating fluid is presented considering the viscoelastic property of the nanotubes using Kelvin–Voigt model. SWCNTs are placed in longitudinal magnetic fields and modeled by sinusoidal shear deformation beam theory (SSDBT) as well as modified couple stress theory. The effect of slip ...

OBJECTIVE We attempted to determine the molecular mechanism of fluid shear stress-induced lipocalin-type prostaglandin D synthase (l-PGDS) expression in vascular endothelial cells. METHODS AND RESULTS We examined the promoter region of the l-PGDS gene by loading laminar shear stress (20 dyne/cm2), using a parallel-plate flow chamber, on endothelial cells transfected with luciferase reporter v...

The endothelial lining of blood vessels is constantly exposed to fluid mechanical forces generated by flowing blood. In vitro application of fluid shear stresses to cultured endothelial cells influences the expression of multiple genes, as reflected by changes in their steady-state mRNA levels. We have utilized the B chain of platelet-derived growth factor (PDGF-B) as a model to investigate the...