OBJECTIVE Rheumatoid arthritis (RA) is one systemic auto-immune disorder featured as chronic synovitis and can destruct joint cartilage. Fibroblast-like synoviocyte (FLS) secretes various factors affecting chondrocyte matrix and degradation. This study thus investigated the effect of interleukin-17A (IL-17A) on FLS and osteoclast. MATERIALS AND METHODS Type II collagen-induced arthritis (CIA)...

BACKGROUND The role of religious beliefs in the prevention of HIV and attitudes towards the infected has received considerable attention. However, little research has been conducted on Faith Leaders' (FLs) perceptions of antiretroviral therapy (ART) in the developing world. This study investigated FLs' attitudes towards different HIV treatment options (traditional, medical and spiritual) availa...

In this paper, we introduce a new method for cross-layer design in mobile ad hoc networks. We use fuzzy logic system (FLS) to coordinate physical layer, data-link layer and application layer for cross-layer design. Ground speed, average delay and packets successful transmission ratio are selected as antecedents for the FLS. The output of FLS provides adjusting factors for the AMC (Adaptive Modu...

This paper uses a Jle.rrhle leust squares (FLS) time-varying linear regression technique to investiaate coefficient stabilitv for the Goldfeld U.S. money demand model over the period 1959:62 to 19X5:Q3. Time paths traced out by the FLS coefficient estimates exhibit shifts in 1974 and 1983; but these shifts are small relative to a persistent downward trend in the estimated coefficient for the in...

Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of rheumatoid arthritis (RA). Increased cell migration and degradation of extracellular matrix are fundamental to these processes. The class I PI3Ks control cell survival, proliferation, and migration, which might be involved in cartilage damage in RA. PI3Kδ isoform was recently id...

In this research work, an approach for fire detection and estimation robots is presented. The approach is based on type-2 fuzzy logic system that utilizes measured temperature and light intensity to detect fires of various intensities at different distances. Type-2 fuzzy logic system (T2 FLS) is known for not needing exact mathematic model and for its capability to handle more complicated uncer...

OBJECTIVE To examine the impact of 5-Aza-2'-deoxycytidine (5-AzadC) on methylation status of miR-124a genes in rheumatoid arthritis (RA) associated fibroblast-like synoviocytes (FLS) and its effect on RA-FLS proliferation and TNF-α expression. MATERIALS AND METHODS FLS were isolated from seven RA-derived synovial tissues and cultured in vitro. The expression of miR-124a was measured by real t...

Extreme learning machines (ELM), as a learning tool, have gained popularity due to its unique characteristics and performance. However, the generalisation capability of ELM often depends on the nature of the dataset, particularly on whether uncertainty is present in the dataset or not. In order to reduce the effects of uncertainties in ELM prediction and improve its generalisation ability, this...