This paper provides an overview of recent results for relay-delay systems. In a first section, simple examples illustrate the problems induced by delays in the synthesis of sliding mode controllers. Then, a brief overview of the existing results shows the present advances and limits in this domain. The last parts of the paper are devoted to new results: first, for systems with state delay, then...

Objective: The present research work is focused to develop in situ raft gel of lafutidine. Sodium alginate one the critical components for development system. Methods: formulation was prepared using hydrophilic polymers such as ethyl cellulose, HPMC K4M, and chitosan. formulations were subjected evaluation characteristics pH, vitro gelling time, viscosity, density, strength, drug-polymer compat...

Objective: The recent study's objective was to optimize and formulate a controlled-release gastro-retentive floating tablet of RG using central composite design, which provides continuous release Repaglinide for up 24 h. Methods: (RG-GRF Tablet) prepared by direct compression method. optimization carried out three-factor three-level Central Composite design. amount Eudragit RSPO (A), HPMC K-100...

This paper presents methods for estimating time delay margin for adaptive control of input delay systems with almost linear structured uncertainty and a step input reference command signal. The bounded linear stability analysis method seeks to represent an adaptive law by a locally bounded linear approximation within a time window. The time delay margin of this input delay system represents a l...

The main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of Methocel® K15, Ethocel® standard 7FP premium, Eudragit ® RS100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. Risperidone floating tablets were formulated by wet granulati...

in the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including hydroxypropyl methylcellulose k4m, carbapol 934, and polyvinylpyrrolidone. optimized formulation showed good floating prope...

abstract                                                                               the new drug delivery systems have been developed, which can remain in the stomach for prolonged period of time. the effervescent floating tablet is one of these systems. iron deficiency anaemia is a common disease in the world. ferrous sulphate is the most common ferrous preparation used to treat and prevent...

In a recent paper we presented the first adaptive control design for an ODE system with a possibly large actuator delay of unknown length. We achieved global stability under full state feedback. In this paper we generalize the design to the situation where, besides the unknown delay value, the ODE also has unknown parameters, and where trajectory tracking (rather than equilibrium regulation) is...