Scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also k...

Floating matrix tablets or stomach specific drug delivery systems are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug, especially useful for achieving controlled plasma level as well as improving bioavailability. Due to low gastric retention time, the bioavailability of acyclovir is low as the large portion of dr...

The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than juice and remain on for a long period of time without impacting the gastric-emptying rate increasing bioavailability. Gastro-retentive microspheres particularly suitable continuous or late release oral formulations with blending versatility achieve various pat...

Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. ...

The objective of this investigation was to develop the hollow microspheres as a new dosage form of floating drug delivery system with prolonged stomach retention time. Hollow microspheres containing ranitidine hydrochloride were prepared by solvent evaporation method using Eudragit RLPO dissolved in a mixture of dichloromethane and ethanol. The maximum yield and drug loading amount of hollow mi...

Oral drug delivery route is the most preferable route of drug delivery. It is due to various advantages of this route like ease of administration, patient compliance and flexibility in the formulations. Oral dosage form has really progressed from immediate release to site-specific delivery. The recent scientific and patented literature concluded that an increased interest in novel dosage forms ...