when intracranial pressure (icp) was uncontrollable among patients with severe traumatic brain injuries (stbi) and especially if it raises above 40 mmhg 100% morality was reported. eighty four percent of head injured patients would die if their initial icp is greater than 25 mm hg. decreasing icp through decompressive craniectomy (dc) theoretically may revert increased icp to normal and decreas...

traumatic brain injury (tbi) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. in vitro models of tbi can help us to describe the pathobiological mechanisms. in vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. other advantages of in vitro mo...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...

background & aim: using pharmaceutical agents in treatment of aphasia has caught the attention of many neurologists and neuroscientists. this short review study has sought the role of pharmacotherapy in treatment of aphasia, a linguistic impairment after acquired brain lesions. the pharmacological principles and mechanisms related to the effects of drugs used in aphasia rehabilitation are point...

conclusions available data implies that restorative therapies should focus on multiple targets and different intervals after injury. yet, if we understand the key and basic origin of the injury, we may develop effective, complete, safe, and continual procedures. materials and methods we downloaded and reviewed more than 170 full textbooks and articles in english from the literature pubmed, and ...

to determine the prevalence of pituitary hormone deficiencies after moderate traumatic brain injury (tbi). we conducted a prospective cohort and included 75 patients with moderate tbi with gcs between 9 and 13 who referred to emergency department of shariati hospital, tehran/iran, during 2004-2007. pituitary hormones were assessed 3 and 6 months after injury. in 3rd month post-injury, 39 cases ...

seizure activity has been proposed to result in the generation of reactive oxygen species (ros), which then contribute to seizure-induced neuronal damage and eventually cell death. although the mechanisms of seizure-induced ros generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. we aim to determine the sources of seizure-induced ros and ...

fracture of the proximal humerus associated with vascular injury has rarely been reported in children, and only two cases have been reported in the literature. in adults this combination has been reported more frequently. we present the case of a 14 year old boy with proximal humeral epiphyseal separation and axillary artery injury.

introduction: there are several different molecular pathways in tissue damage by ischemic brain injury. the use of antioxidants and free radical scavengers are a matter of attention by some researchers. crocus sativus (saffron) is used previously for protective effects in ischemia state by some researchers. to assess pathologic aspects of neuroprotection of saffron in some susceptible brain are...

conclusions penetrating trauma from wooden fragments provides a diagnostic challenge. a stubborn discharge from a wound must always raise the suspicion of retained fragment. early and appropriate surgical exploration is imperative. introduction in contrast with victims of major trauma, patients who suffer minor injuries receive little specialist input. in most cases, this causes no difficulty, ...