In this work the dynamic flow as well as the particle motion and deposition in a commercial dry powder inhaler, DPI (i.e., Turbuhaler) is described using computational fluid dynamics, CFD. The dynamic flow model presented here is an extension of a steady flow model previously described in Milenkovic et al. (2013). The model integrates CFD simulations for dynamic flow, an Eulerian-fluid/Lagrangi...

On-line monitoring and control of particle shape and size distribution is important in pharmaceutical and fine chemical manufacturing. In this paper, we describe a methodology for real-time estimation of particle quality variables during crystallization using inline process video-images. Our approach integrates image analysis techniques with multivariate statistical techniques to quantify parti...