Dr. Macica states: “The formation of enthesophytes was our focus, with a major emphasis on characterizing the cellular changes that occur in enthesophyte formation using the murine model of XLH, Hyp mice. We have found that mineralization, while thought to originate from bone, is actually due to both an expansion of fibrocartilage cells that express the FGFR3 receptor and an increase in alkalin...

The injection of contrast material into the navicular bursa, accompanied by a subsequent radiographic examination, provides new and relevant information about pathologic damage to the navicular flexor fibrocartilage and the deep digital flexor tendon. It is the only diagnostic method currently being used that can determine whether adhesions have occurred between the navicular bone and deep flex...