BACKGROUND Stroke is a devastating disease with increasing incidence and prevalence due to population aging. Even with the best care, a proportion of patients dies or is left with significant neurological and cognitive disability. Organization of stroke centers markedly improved outcomes worldwide. We initiated a 'lysis alarm' program in September 2013 at our medical center. METHODS This is a...

Creatine kinase isoforms markers, including MB2 concentration, MB2/MB1 and MM3/MM1 ratios, and MT index (based on the "tissue" M subunits), were measured in serial specimens from 207 patients receiving thrombolytic therapy followed by acute angiography. The slope of release showed a significant relation (P < 0.05) between MB2 concentrations and patency, graded as TIMI 0 through TIMI 3; with reg...

Doctors managing acute stroke are expected to recognise signs of early infarction on CT before choosing thrombolytic treatment, according to recent trials and guidelines. The ability of 13 physicians and two neuroradiologists to recognise early infarct signs and decide whether patients should be randomised in a hypothetical stroke treatment trial was tested. Only 65% of the CT scans from 14 str...

The Western Washington Intracoronary Streptokinase randomized trial1 first demonstrated that intracoronary thrombolytic therapy improved survival for patients presenting within 12 hours of symptom onset of acute myocardial infarction (MI). Perhaps equally important, this invasive study demonstrated that in-hospital and long-term survival was greatly improved in patients with patent infarctrelat...

BACKGROUND AND PURPOSE Prior studies have shown that patients with mild ischemic stroke have substantial disability rates at hospital discharge. We sought to determine disability rates at 90 days among patients not treated with thrombolytic therapy and explore the role of early neurological worsening. METHODS We reviewed a prospective cohort of 136 consecutive patients with mild deficits (Nat...

BACKGROUND AND PURPOSE Arterial recanalization and subsequent reperfusion have extensively demonstrated their ability to restore the brain function when performed shortly after acute ischemic stroke. However, arterial recanalization does not necessarily lead to brain tissue reperfusion. SUMMARY OF REPORT This review provides an update of current approaches to improve the efficacy profile of b...

Brown alga Fucus evanescens, widespread in the Far Eastern seas of Russia, is valuable source of sulfated polysaccharides—fucoidans with beneficial biological activities. The most homogenous fraction of fucoidan from F. evanescens was shown to be molecule containing linear main chain of alternating 2-sulfated 1,3and 1,4-linked α-L-fucose residues. Few sulfate groups were found in position 4 of ...

An ever-growing proportion of patients with acute myocardial infarction undergo coronary thrombolysis; recent estimates indicate that in the United States, about 20% of the annual 700,000 patients with myocardial infarctions receive such therapy.' Even though thrombolysis reduces short-term mortality by approximately 20-30%,2-5 each year a large number of patients leave the hospital with a subs...

Cancer Control 5 pared with cancer patients who do not have a thrombotic event — experience reduced survival.5,6 The seriousness of VTE as a complication in cancer patients is becoming recognized as an important medical issue. That recognition is evidenced in the 2004 publication of The American College of Chest Physicians (ACCP) Conference on Antithrombotic and Thrombolytic Therapy: Evidence-B...