OBJECTIVES The goal of this study was to determine whether chronic inflammation of the vascular wall may be associated with an impaired activation of the fibrinolytic system. BACKGROUND Inflammation plays an important role in the initiation and progression of atherosclerosis, and the fibrinolytic system may prevent local thrombus formation. METHODS We included 50 patients six months after t...

The basal fibrinolytic activity in 17 children with active juvenile chronic arthritis (JCA) was investigated. It was found that patients with JCA, and particularly those with the systemic form, show decreased plasma fibrinolytic activity and a marked increase in plasminogen activator inhibitor. Additionally, it was found that patients with systemic JCA, but not those with the polyarticular or p...

1. A significant in vitro fibrinolytic activity could be obtained in plasma of rats given human fibrinolysin intravenously. 2. Pulmonary métastaseswere produced in a large percentage (81 per cent) of control rats given inoculations intravenously of 100,000 Walker 256 carcinosarcoma cells/ml. When cells were inoculated into animals with marked fibrinolytic activity produced by human fibrinolysi...

This study was performed to assess the effect of chlorpropamide therapy on the fibrinolytic activity of blood of maturity onset diabetics. Normal controls were also studied and the results compared with diabetics. Diabetics were found to have deficient fibrinolytic activity compared with non-diabetics but chlorpropamide did not appear significantly to affect this deficiency either in males or f...

Blood fibrinolytic activity and plasma cortisol levels were investigated during surgical procedures in twenty-three patients who underwent laparotomy. From 30 minutes to 1^ hours of surgical stress, enhancement of fibrinolysis was significantly correlated with increase of plasma cortisol levels. There were no exceptions to this pattern. The changes in fibrinolytic activity and plasma cortisol l...

Adverse changes in coagulation and fibrinolytic factors are thought to contribute to the increased risk of cardiovascular disease and atherothrombosis with age. We tested the hypothesis that such age-related changes in specific coagulation and fibrinolytic factors are absent in physically active women. Resting levels of plasma fibrinogen, tissue-type plasminogen activator (t-PA) antigen and act...

To elucidate the mechanism underlying the action of dietary vinegar on antithrombotic activity, acetic acid, the main acidic component of dietary vinegar, was used to determine antiplatelet and fibrinolytic activity. The results revealed that acetic acid significantly inhibits adenosine diphosphate (ADP)-, collagen-, thrombin-, and arachidonic acid (AA)-induced platelet aggregation. Acetic acid...

Fibrinolysis is the process of fibrin digestion by an enzyme system present in the blood. Although fibrinolytic activity has been found in the normal, and in many pathological states, its role remains obscure. It seems likely, however, that such a process may take part in the normal hamostatic equilibrium of the body and may be operative in the processes of resolution and healing (Astrup, 1956)...

ARECENTLY published tabulation' of simple organic compounds reported to induce some weak fibrinolytic activity includes only compounds known to influence vasomotion (procaine, epinephrine, diethylaminoethanol). Studies in our laboratory concerning the influence of vasomotor drugs on the clotting mechanism have resulted in the observation that intravenously administered nicotinic acid induces ra...

Imbalance between intra-alveolar procoagulant activity (PCA) and fibrinolytic activity may lead to fibrin deposition, as described in several pneumopathies, and may eventually contribute to fibrotic changes as observed in Pneumocystis carinii pneumonia (PCP). The aim of our study was to compare these activities in bronchoalveolar lavages of human immunodeficiency virus (HIV)-positive and HIV-ne...