The basal fibrinolytic activity in 17 children with active juvenile chronic arthritis (JCA) was investigated. It was found that patients with JCA, and particularly those with the systemic form, show decreased plasma fibrinolytic activity and a marked increase in plasminogen activator inhibitor. Additionally, it was found that patients with systemic JCA, but not those with the polyarticular or p...

A simple screening method for determining the fibrinolytic activity of plasma is described. A streptokinase activated system is used, which measures the result of the interplay of all components of the fibrinolytic system with the exception of activators, which are added in excess. Mean lysis time and standard deviation with this method is 6.9 +/- 1.4 min. The sensitivity of the method in detec...

ST-Segment Elevation Myocardial Infarction The Evolution from Fibrinolytic Therapy to a Fibrinolytic Strategy for Patients with Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation published online August 26, 2014; Circulation. http...

1. A significant in vitro fibrinolytic activity could be obtained in plasma of rats given human fibrinolysin intravenously. 2. Pulmonary métastaseswere produced in a large percentage (81 per cent) of control rats given inoculations intravenously of 100,000 Walker 256 carcinosarcoma cells/ml. When cells were inoculated into animals with marked fibrinolytic activity produced by human fibrinolysi...

This study was performed to assess the effect of chlorpropamide therapy on the fibrinolytic activity of blood of maturity onset diabetics. Normal controls were also studied and the results compared with diabetics. Diabetics were found to have deficient fibrinolytic activity compared with non-diabetics but chlorpropamide did not appear significantly to affect this deficiency either in males or f...

The distribution of plasminogen activator in fresh human prostatic tissue has been studied, using a histological technique. The vascular endothelium consistently showed fibrinolytic activity while inconstant and lesser activity arose from the epithelial cells of glands and ducts. Increased epithelial activity was often accompanied by evidence of trauma. Activity of the secretions was insignific...

Blood fibrinolytic activity and plasma cortisol levels were investigated during surgical procedures in twenty-three patients who underwent laparotomy. From 30 minutes to 1^ hours of surgical stress, enhancement of fibrinolysis was significantly correlated with increase of plasma cortisol levels. There were no exceptions to this pattern. The changes in fibrinolytic activity and plasma cortisol l...

Plasma fibrinolytic activity and plasma inhibitory activity against urokinase and tissue activator were measured in primigravidae with moderate or severe pre-eclampsia and in gestation-matched primigravidae with uncomplicated pregnancy. The mean levels of fibrinolytic activity and inhibitory activity against urokinase and tissue activator did not differ significantly between the pre-eclampsia a...

The distribution of fibrinolytic activity in tissues may be studied by the technique of fibrinolysis autography (Todd, 1958, 1959, 1960). This is a histological method in which a section of fresh tissue is incubated in contact with a thin layer of bovine fibrin. During incubation discrete zones of digestion appear in the fibrin, related presumably to concentrations of fibrinolytic enzymes in th...

The term " thrombolytic therapy " refers to the attempted removal of preformed intravascular fibrin occlusions using fibrinolytic agents. Several substances have been described as inducing a fibrinolytic state in the peripheral blood ; however, for only a few of these (namely, the plasminogen activators streptokinase and urokinase) was it proved beyond reasonable doubt that administration resul...