THE heart muscle was conceptualized as an anatomical syncytium for many years (Heidenhain, 1901; Godlewsky, 1902). With the development of electron microscopy, it was proved that cardiac fibers are composed of isolated cells separated by specialized zones—the so-called intercalated discs (Sjostrand and Andersson, 1954). The discs comprise three junctional specializations: (1) the macula adhaere...

Genotoxicity is the most commonly used endpoint to predict the carcinogenicity of chemicals. The International Conference on Harmonization (ICH) M7 Guideline on Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk offers guidance on (quantitative) structure-activity relationship ((Q)SAR) methodologies that predict the outcome of b...

There is a rapidly growing need to communicate the public and policymakers on nature impact of climate change its associated extremes, which manifest themselves across essential Food-Energy-Water Systems (FEWS). The complexity this nexus demands analytical tools that can capture essence FEWS with system, may be difficult stage implement from computationally efficient point-of-view. Reduced Comp...

In the food-energy-water (FEW) nexus, livestock has a dominant place. It is generally considered as water, energy and land-intensive. Aquaculture could provide additional animal protein contribute to meeting food demand. However, aquaculture requires natural resources causes freshwater pollution due aquafeed, fertilizer, hormone use. This study assesses sustainability of using indicators water ...

Managing urban water systems in which stormwater, wastewater, and drinking sectors affect each other is a difficult task that requires the right modeling tools for decision making. Integrated management models (IUWMs) are allow makers to demonstrate effectiveness of various management, operational design strategies. Although useful tools, wide range available with many different capabilities ma...

INTRODUCTION The Choosing Wisely campaign currently recommends avoiding computed tomography (CT) of the head in low-risk emergency department (ED) patients with minor head injury, based on validated decision rules. However, the degree of adherence to this guideline in clinical practice is unknown. The objective of this study was to evaluate adherence to the Choosing Wisely campaign's recommenda...

NeXuS[1] is a framework for the development of Augmented Reality (AR) applications that utilises perceptive intentional agents to create rich interactive environments where traditional boundaries between virtual and physical spaces may be overcome. The NeXuS framework demonstrates how behavioural realism can be achieved by placing such agents within an AR environment. Fig. 1 illustrates how a N...

Nutrients and water found in domestic treated wastewater are valuable and can be reutilized in urban agriculture as a potential strategy to provide communities with access to fresh produce. In this paper, this proposition is examined by conducting a field study in the rapidly developing city of Hyderabad, India. Urban agriculture trade-offs in water use, energy use and GHG emissions, nutrient u...

Article history: Received 27 July 2009 Received in revised form 1 September 2009 Accepted 16 September 2009 Available online 3 October 2009 Well-being is a construct spanning multiple disciplines including psychology, economics, health, and public policy. In many ways, well-being is a nexus of inter-correlated variables, much like the g nexus. Here, we created an index of well-being for the geo...

Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.