Background: This study aimed to evaluate the reaction of organism of laboratory animals on deuterium-depleted drinking diet. To assess the cell energy metabolism, the effect of a liquid medium with different deuterium contents on isolated liver mitochondria of random bred rats and Wistar rats was studied. Methods: This experimental study on the effect of deuterium-depleted drinking water (DDW) ...

The concerns about the possible risk of manufactured nanoparticles (NPs) have been raised recently. Nano- and micro-sized copper oxide (CO and CONP) are widely used in many industries. In this regard, in-vitro studies have demonstrated that CONP is a toxic compound in different cell lines. Despite their unique properties, NPs possess unexpected toxicity profiling relative to the bulk m...

Abstract The endoplasmic reticulum (ER) and mitochondria interact exchange material in healthy neurons. Mutants for the ER protein Creld show strong, Parkinson’s disease-like locomotion deficits. We found that facilitates phospholipid flux at ER-mitochondria interface, thereby enabling formation of hydrogen peroxide respiratory complex I, which is required dopaminergic neuron activity.

Mitochondria continuously change shape, position, and matrix configuration for optimal metabolite exchange. It is well established that changes in mitochondrial metabolism influence mitochondrial shape and matrix configuration. We demonstrated previously that inhibition of mitochondrial complex I (CI or NADH:ubiquinone oxidoreductase) by rotenone accelerated matrix protein diffusion and decreas...

In the genetic modification of plant cells, mitochondrion is an important target in addition to nucleus and plastid. However, gene delivery into mitochondria cells has yet be established by conventional methods, such as particle bombardment, because small size high mobility mitochondria. To develop efficient mitochondria-targeting signal (MTS) that functions we designed artificial peptide (LURL...

The objective: to study pathological changes and compensatory-adaptive reactions in the structural ultrastructural components of placental barrier pregnant women with gestational arterial hypertension, who received magnesium preparations. Materials methods. 100 patients hypertension were examined. presence deficiency these was determined by results our questionnaires.Pathomorphological electron...

Thyroid hormones regulate adult metabolism partly through actions on mitochondrial oxidative phosphorylation (OXPHOS). They also affect neurological development of the brain, but their role in cerebral OXPHOS before birth remains largely unknown, despite increase energy demand during neonatal period. Thus, this study examined prepartum hypothyroid fetal sheep. Using respirometry, Complex I (CI)...

Placenta is a unique organ, without which the very phenomenon of human pregnancy impossible. Semiallogeneous nature, localization placenta, complex and heterogeneous cellular composition determines its multifaceted role in course physiological pregnancy, indicates importance studying this organ number reproductive pathologies. The purpose review was to analyze literature sources illustrating en...

arsenic exposure mainly through food and water has been shown to be associated with increased incidence of numerous cancers and non-cancer harmful health. it is also used in cancer chemotherapy and treatment of several cancer types due to its apoptogenic effects in the various cancer and normal cell lines. we have already reported that liver is the storage site and important target organ in as ...

background: the ultrastructural analysis of cultured follicles could direct us to understand subcellular changes during in vitro culture. objective: this study was done to verify the ultrastructural characteristics of in vitro cultured mouse isolated preantral follicles in co-culture system in the presence and absence of leukemia inhibitory factor (lif) materials and methods: mechanically isola...