Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...

In recent years, there has been much importance placed on finding novel therapeutic agents from F. asafoetida plant and it’s common name is Asafoetida. It is commonly used as a traditional medicine in Iran, Afghanistan and India. It is herbaceous plant of the Umbelliferae family and its root contains oleo gum resin which has many medicinal properties. The resin is solid or semisolid with alliac...

objective: the genus of ferula belongs to the tribe peucedaneae, subfamily of apioideae and family of umbelliferae with 133 species distributed throughout the mediterranean area and central asia, especially in the former ussr and neighboring countries such as iran. the popular persian name of the most of these species is “koma”. in this research we tried to isolate and elucidate the structure o...

in iranian traditional medicine, there are some report regarding the anticonvulsant effect of ferula gummosa boiss. in this study, anticonvulsant activity, neurological deficits and lethality of the root acetone extract of this plant were evaluated in mice. the extract exhibited dose-dependent prevention of tonic seizures induced by pentylenetetrazole (ed50 = 154.4 mg/kg). however, the extract ...

background: ferula persica has been used in traditional medicine for treatment of high blood pressure. in this study acute and chronic effect of aqueous f. persica extract on bp of hypertensive rats and its possible mechanism of action have been investigated. methods: eighty two male wistar rats were divided into 12 experimental groups. hypertension was induced by goldblatt method in the anesth...