نتایج جستجو برای: ferroportin
تعداد نتایج: 765 فیلتر نتایج به سال:
Iron-induced oxidative stress is thought to play a crucial role in the pathogenesis of Parkinson's disease. Our previous studies demonstrated that decreased expression of ferroportin 1 contributes to 6-hydroxydopamine induced intracellular iron accumulation and that decreased ferroportin 1 expression is caused by increased expression of iron regulatory protein 1. Iron regulatory protein 1 is a ...
The ferritin level, a protein responsible for iron metabolism and storage, is sensitive indicator of overload in various pathological conditions. In leukemia, levels increase with disease stages can predict survival after transplantation. Leukemia-induced dysregulation the ferroportin-hepcidin regulatory axis results intracellular accumulation, activation reactive oxygen species (ROS)-related s...
BACKGROUND The control over iron homeostasis is critical in host-pathogen-interaction. Iron plays not only multiple roles for bacterial growth and pathogenicity, but also for modulation of innate immune responses. Hepcidin is a key regulator of host iron metabolism triggering degradation of the iron exporter ferroportin. Although iron overload in humans is known to increase susceptibility to Bu...
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