The aim of the present investigation was to investigate the effect of chemical enhancers on the release of glipizide through transdermal matrix patch using different ratio of different chemical enhancers. L-menthol, oleic acid and n-octanol were tried over the glipizide matrix patch. The used concentrations of L-menthol and oleic acid were 1%, 1.5% and 2.0% and concentration of n-octanol was 1%...

This study aimed to investigate the perioperative analgesic effect of a buprenorphine transdermal patch in patients who underwent simple lumbar discectomy.In total, 96 patients were randomly divided into parecoxib intravenous injection (Group A), oral celecoxib (Group B), and buprenorphine transdermal patch groups (Group C). The pain status, degree of satisfaction, adverse effects, and conditio...

This study examines outcome measures of abstinence among studies reporting 12-month outcomes of the nicotine transdermal patch using different measures of effectiveness. This was achieved by reviewing published randomized controlled studies reporting 1-year abstinence rates of the nicotine transdermal patch. Comparisons are made across studies of three outcome measures used to report abstinence...

      Insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. The prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. The transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. Plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were in...

BACKGROUND Acute and severe pain is common in patients postoperatively and should be correctly managed. In the past years studies on preparing better postoperative pain control have resulted in development of postoperative pain management guidelines. Perhaps, one of the major improvements in managing postoperative pain is the development of the patient-controlled analgesia systems (PCA), especi...

The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surface topography of the patches was examined by scanning electron microscopy (S...

The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surface topography of the patches was examined by scanning electron microscopy (S...