Insulin-like growth factor binding protein-5 (IGFBP-5) is an osteoblast secretory protein that becomes incorporated into the mineralized bone matrix. In osteoblast cultures, IGFBP-5 stimulates cell proliferation by an IGF-independent mechanism. To evaluate whether IGFBP-5 can stimulate osteoblast activity and enhance bone accretion in a mouse model of osteoblast insufficiency, daily subcutaneou...

The aim of our study was to investigate whether placing of the femoral component of a hip resurfacing in valgus protected against spontaneous fracture of the femoral neck. We performed a hip resurfacing in 20 pairs of embalmed femora. The femoral component was implanted at the natural neck-shaft angle in the left femur and with a 10 degrees valgus angle on the right. The bone mineral density of...

BACKGROUND The Cissus sicyoides, popularly called insulin plant, the drink is widely used in folk medicine to control glycemia. However, there are not enough datas about the effect of Cissus sicyoides on bone physiology. Thus, the goal was evaluate the glycemia and femur parameters in male rats. MATERIAL AND METHODS Wistar male rats with 12 weeks were divided control group (C) and treated wit...

1. The mean attenuation coefficients of trabecular and cortical bone in the radius were measured in 32 female patients with fractured proximal femur, and in 28 age-matched female controls, with a special-purpose computed tomography-scanner. 2. The largest difference between the two groups was in the mean attenuation coefficients for trabecular bone in the distal radius. The mean value for fract...

BACKGROUND Cyclosprin A (CsA) has been widely used clinically to treat the patients who have undergone organ transplantation or acquired autoimmune disease. The purpose of this study is to determine the effects of three different doses of CsA (1.5, 7.5, 15 mg/kg body weight) on the skeletal biomechanical proprieties at different anatomic sites in rats. METHODS Fifty-six male 3-month-old Wista...

Aim: We aimed to examine the presence, number, anatomic location of nutrient foramen in long bones upper and lower limbs calculate index. Materials Methods: Our study was conducted on a total 295 bones, including 25 clavicle, 59 humerus, 49 radius, 32 ulna, femur, tibia, 22 fibula. The number each bone, direction its opening were determined recorded. All photographed with millimeter ruler. bone...

Background: Fractures occur due to trauma or physical activity with excessive pressure on the bone, including collisions, beatings, falls, irregular tilted positions, dislocations, withdrawals, and abnormal bone weakness (pathological fractures). This study aims analyze effect of Breathing Relaxation spiritual-based reducing pain scale in patients postoperative femoral fractures. Methods: A qua...

The relation between the bone histomorphometric profile of the iliac crest and regions of the proximal femur was investigated. In the proximal femur four blocks were selected, representing the subchondral principal compressive (SPC) and tensile (SPT) regions, the zone near the medial cortex in the principal compressive region (MPC), and the zone medial to the greater trochanter (MGT). Undecalci...

The femur, a rib, and a third metacarpal were collected from 108 barrows (initial weight = 57 kg) and analyzed to determine the effects of porcine somatotropin (pST) and dietary lysine on bone mineralization and mechanical properties. In Exp. 1, pigs were injected daily with 4 mg of pST and fed diets containing 1.0% Ca and .9% P and either .6, .8, 1.0, 1.2, or 1.4% lysine. Control pigs (placebo...

Osteoarthrosis (OA) is a multi-factorial disease characterized by the progressive loss of articular cartilage and the development subchondral sclerosis, intra-osseous cysts and osteophytes. In addition to changes in cartilage which occur in OA, it is suggested that early changes are seen in the adjoining subchondral and trabecular bone (1). In this work we develop, optimize and extend MR techni...