The Finite Cell Method (FCM), which combines the fictitious domain concept with high-order p-FEM, permits the effective solution of problems with very complex geometry, since it circumvents the computationally expensive mesh generation and guarantees exponential convergence rates for smooth problems. The present contribution deals with the coupling of the FCM approach, which has been applied so...

The dynamics of beams that undergo large displacements is analyzed in frequency domain and comparisons between models derived by isogeometric analysis and p-FEM are presented. The equation of motion is derived by the principle of virtual work, assuming Timoshenko’s theory for bending and geometrical type of nonlinearity. As a result, a nonlinear system of second order ordinary differential equa...

BACKGROUND Several epidemiological studies have evaluated the association between the NAD(P)H oxidase p22 phox gene C242T polymorphism and the risk of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and carotid atherosclerosis with T2DM (CA), but the results are inconclusive. This meta-analysis was therefore designed to clarify these controversies. METHODS Systematic searches were...

LA-related protein 1 (LARP-1) belongs to an RNA-binding protein family containing a LA motif. Here, we identify LARP-1 as a regulator of sex determination. In C. elegans hermaphrodites, a complex regulatory network regulates the switch from sperm to oocyte production. We find that simultaneous depletion of larp-1 and the Nanos homologue nos-3 results in germline masculinization. This phenotype ...

BACKGROUND Accurately solving the electroencephalography (EEG) forward problem is crucial for precise EEG source analysis. Previous studies have shown that the use of multicompartment head models in combination with the finite element method (FEM) can yield high accuracies both numerically and with regard to the geometrical approximation of the human head. However, the workload for the generati...

Disk brake squeal noise is mainly due to unstable friction-induced vibration. A typical disk brake system includes two pads, a rotor, a caliper and a piston. In order to predict if a disk brake system will generate squeal, the finite element method (FEM) is used to simulate the system. At the contact interfaces between the pads and the rotor, the normal displacement is continuous and Coulomb’s ...