نتایج جستجو برای: fecal calprotectin

تعداد نتایج: 26991  

2013
Gea A Holtman Yvonne Lisman-van Leeuwen Boudewijn J Kollen Johanna C Escher Angelika Kindermann Patrick F van Rheenen Marjolein Y Berger

BACKGROUND Low disease prevalence and lack of uniform reference standards in primary care induce methodological challenges for investigating the diagnostic accuracy of a test. We present a study design that copes with these methodological challenges and discuss the methodological implications of our choices, using a quality assessment tool for diagnostic accuracy studies (QUADAS-2). DESIGN Th...

Journal: :middle east journal of digestive diseases 0
hamed zamani gilda barzin mahsa yousefinia ashraf mohammadkhani mohammad reza ostovaneh amir houshang sharifi

abstract background ulcerative colitis (uc) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. it is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. the aim of the current study is to...

Journal: : 2023

In recent decades, there has been a steady increase in the incidence of ulcerative colitis worldwide. The purpose work was to analyze literature data on modern features treatment colitis, as well present our own results and cases from practice. Mesalazine remains mainstay remission often its induction patients with colitis. Currently, nature is determined by target level remission. fact onset e...

2014
Kousaku Kawashima Shunji Ishihara Takafumi Yuki Koji Onishi Yoshinori Kushiyama Hirofumi Fujishiro Youichi Miyaoka Mika Yuki Yoshinori Komazawa Takashi Tanimura Hiroki Sonoyama Yasumasa Tada Ryusaku Kusunoki Akihiko Oka Nobuhiko Fukuba Naoki Oshima Ichiro Moriyama Yoshikazu Kinoshita

PURPOSE Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA) with a time-dependent release formulation (time-5-ASA). We examined whether pH-5-ASA is effective for active ulcerative colitis (UC) in patients resistant to time-5-ASA. METHODS We retrospectively and prospectively analyzed the efficacy of pH-5-ASA in mildly to moderately act...

Journal: :Journal of clinical gastroenterology 2012
Anna Licata Claudia Randazzo Maria Cappello Vincenza Calvaruso Giuseppe Butera Ada M Florena Sergio Peralta Calogero Cammà Antonio Craxì

BACKGROUND Surrogate markers of colorectal inflammation are increasingly being recognized as important in differentiating organic from functional intestinal disorders. Fecal calprotectin (FC) can be easily measured in the stool, being released by leukocytes in inflammatory conditions. AIM We evaluated FC as an index of inflammation in consecutive outpatients referred for colonoscopy for chron...

2017
Sun-Ho Lee Min-Ju Kim Kiju Chang Eun Mi Song Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Byong Duk Ye

BACKGROUND We aimed to evaluate the role of fecal calprotectin (FC) as a noninvasive marker for the disease activity of ulcerative colitis (UC) in a Korean cohort. METHODS A total of 181 fecal samples were collected from 181 consecutive UC patients between April 2015 and September 2016. FC levels were measured using the Quantum Blue® Calprotectin rapid test. The laboratory test results, parti...

2016
Bruce E. Sands Shashidhar Joshi Jonathan Haddad Johannes M. Freudenberg Deepa Elizabeth Oommen Ethan Hoffmann Stewart W. McCallum Eric Jacobson

BACKGROUND Sirtuins are a class of proteins with important physiologic roles in metabolism and inflammation. Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation is an unexplored therapeutic approach for the treatment of ulcerative colitis (UC). METHODS Patients with mild to moderately active UC were blindly randomized to 50 mg or 500 mg daily of SRT2104, a se...

Calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. It has been reported that this protein has an apoptotic activity in tumor cells. Since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on HT29/219 and SW742 colon carcinoma and adenocarcinoma cell li...

2017
Imran Siddiqui Hafsa Majid Shahab Abid

Gastrointestinal (GI) diseases comprise a large spectrum of clinical conditions ranging from indigestion to inflammatory bowel diseases (IBDs) and carcinomas. Endoscopy is the usual method employed to diagnose these condition. Another noninvasive way to assess and diagnose GI conditions are fecal biomarkers. Fecal biomarkers provide information regarding a specific disease process and are perha...

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