Introduction : Nowadays, using drug delivery is an essential method to improve cancer therapy through decreasing drug toxicity and increasing efficiency of treatment. Silibinin (C25H22O10), a polyphenolic flavonoid which is isolated from the milk thistle plant, has various applications in cancer therapy but it has hydrophobic structure with low water solubility and bioavailability. To increase ...

This study was undertaken to evaluate the biological potency of two synthetic human growth hormone-releasing factors, hGRF (1-44)NH2 and hGRF (1-29)NH2, on growth hormone (GH) release in young dairy heifers (n = 10) and pigs (n = 10). In each species, the GH response to an iv injection (0, .067, .2, .6 and 1.8 nmol.kg-1 body weight) of each peptide was evaluated in a double 5 X 5 Latin square d...

Superparamagnetic nanorings of polystyrene/Fe3O4 composite were synthesized by miniemulsion polymerization. The nanoring structure was characterized by using transmission electron microscopy, scanning electron microscopy, and atomic force microscopy. The results of X-ray diffraction identified the magnetic constituent of as-synthesized composite nanorings as Fe3O4. The magnetization measurement...

To explore whether the magnetic nanoparticles of Fe3O4 (MNPs-Fe3O4) loaded with cisplatin can reverse the diaminedichloro platinum (DDP) resistance to multidrug resistance of ovarian carcinoma cells and to investigate its mechanisms. The SKOV3/DDP cells were divided into DDP treatment (DDP group), MNPs-Fe3O4 treatment (MNPs-Fe3O4 group), DDP + MNPs-Fe3O4 treatment (DDP + MNPs-Fe3O4 group), and ...

Improvements in durable lubrication together with minimized wear are essential for obtaining long-term, functioning metallic joint prostheses. To achieve this objective, CoCr surface was functionalized Graphene Oxide (GO) and characterized by FTIR XPS. alloy subjected to alkalinization order generate high hydroxyl content on the surface. XPS revealed reactive OH groups, enabling intermediate co...