This study presents an analysis of the small molecule bioactivity profiles across large quantities of diverse protein families represented in PubChem BioAssay. We compared the bioactivity profiles of FDA approved drugs to non-FDA approved compounds, and report several distinct patterns characteristic of the approved drugs. We found that a large fraction of the previously reported higher target ...

BACKGROUND Selective clinical trial publication and outcome reporting has the potential to bias the medical literature. The 2007 Food and Drug Administration (FDA) Amendment Act (FDAAA) mandated clinical trial registration and outcome reporting on ClinicalTrials.gov, a publicly accessible trial registry. METHODS Using publicly available data from ClinicalTrials.gov, FDA documents, and PubMed,...

In the United States, few Food and Drug Administration (FDA)-approved options exist for the treatment of focal cartilage and osteochondral lesions. Developers of products for cartilage repair face many challenges to obtain marketing approval from the FDA. The objective of this review is to discuss the necessary steps for FDA application and approval for a new cartilage repair product. FDA Guida...

Feature density approximation (FDA) based visual object appearance representation is emerging as an effective method for object tracking, but its challenges come from object’s complex motion (e.g. scaling, rotation) and the consequent object’s appearance variation. The traditional adaptive FDA methods extract features in fixed scales ignoring the object’s scale variation, and update FDA by sequ...