Hemophilia B, an X-linked recessive bleeding disorder, is caused by heterogeneous mutations in the factor IX (F9) gene. Hence, carriers of the disease are usually detected by F9 gene linked RFLP analysis. We aimed to test a set of RFLP markers (DdeI, XmnI, MnlI, TaqI & HhaI), used worldwide for carrier detection, to estimate its heterozygosity in different population groups of India, and identi...

background: hemophilia a and b are the most frequent congenital coagulation disorders. this study was conducted to determine the prevalence of hepatitis b, c and human immunodeficiency viruses among hemophilic patients in hamadan, iran. patients and methods: in this study, patients with hemophilia a and b treated in hamedan hemophilia center, hamedan, iran, were screened for hepatitis b, c and ...

the mean age of ftd onset is much younger than that of alzheimers disease. behavioral disturbances occur in early stages of ftd, and social dysfunction and personality deterioration may ensue. for this reason, it may be misdiagnosed with other psychiatric disorders. therefore, more careful observation and concern is required for proper diagnosis. our report is about a patient who was misdiagnos...

Introduction: The management of a patient with severe hemophilia A inhibitors is challenge for any healthcare professional. present analysis shows the clinical and economic impact therapeutic approach in most critical Cuban Hemophilia Cohort. Objective: To evaluate implementation Emicizumab therapy first patient. Case presentation: Adult who started to use recombinant activated factor VII episo...

Hemophilia is an inherited bleeding disorder caused by the lack of a protein necessary for blood clotting. Gene therapy hemophilia involves introduction healthy gene into patient's cells to produce missing protein. There are two main types hemophilia: ex vivo therapy, which extraction from patient, these in laboratory, and reintroduction modified patient; direct delivery body using viral vector...

diabetes type 2 is a world wide spread disease with a multifactorial pathogenetic evolution. various factors like obesity, physical inactivity and poor lifestyle habits contribute to its development. the aim of this study was to verify if in young healthy sedentary male and female there is positive correlation between family history to type 2 diabetes and an increase in body weight and fat mass...

BACKGROUND Visceral venous aneurysms are exceedingly rare, and until now, there have been no reports of this phenomenon in the adrenal vasculature. This report details the first adrenal venous aneurysm reported in the literature. The aneurysm presented as an 18-cm mass that was initially suspected to be a hematoma or tumor on the basis of the complex medical history of the patient, which includ...

background: factor viii inhibitor is one of the most problems in the treatment of hemophilia. patients with hemophilia who have inhibitors are capable of severe hemorrhage and treatments of these patients are more expensive and more difficult than those patients without inhibitor. the aim of present study was to determine the prevalence of inhibitor and to assess the necessity of screening of t...