The advancements of GPS and GIS technologies provide new opportunities for investigating vehicle trip generation and destination choice at the microscopic level. This research models how land use and road network structure influence non-work, non-home vehicle trip generation and non-work destination choice in the context of trip chains, using the in-vehicle GPS travel data in the Minneapolis-St...

BACKGROUND Translating research evidence into clinical practice (TRIP) is an important initiative for health services so that care delivered is cost-effective, is efficient, and improves patient outcomes. Most TRIP studies have reported on disseminating and implementing clinical practice guidelines, protocols, or care pathways and have been undertaken in acute rather than community settings. ...

We present a constraint programming formulation for the elevator trip origin-destination matrix estimation problem, and study different deterministic and randomized algorithms to solve the problem. An elevator trip consists of successive stops in one direction of travel with passengers inside the elevator. It can be defined as a directed network, where the nodes correspond to the stops on the t...

INTRODUCTION This study answers the question: 'How far must a Canadian woman travel before the risk of a motor vehicle accident (MVA) outweighs the benefits of mammography screening?'. METHODS Numbers needed to screen and false positive rates were extracted from information in the breast screening guidelines from the Canadian Task Force on screening for breast cancer. Motor vehicle accidents ...

The primary objective of the National Airspace System (NAS) is the transportation of passengers and cargo. Since passenger trip time performance is positively correlated with passenger satisfaction, airfare elasticity, and airline profits, it follows that the National Air Space (NAS) performance evaluation, modernization, and consumer protection should be based on passenger trip performance. Pu...

The return trip often seems shorter than the outward trip even when the distance and actual time are identical. To date, studies on the return trip effect have failed to confirm its existence in a situation that is ecologically valid in terms of environment and duration. In addition, physiological influences as part of fundamental timing mechanisms in daily activities have not been investigated...

Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo conversion to a mesenchymal phenotype contributing to wound repair by fibrosis and to cancer cell acquisition of invasive ability. Recently, we showed that type II TGF-β receptor interacting protein-1 (TRIP-1), a protein identified as a phosphorylation target of the TGF-β type II receptor kinase and as a func...

In contrast to white adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and inducible energy expenditure. Obesity is associated with reduction of BAT function; however, it is not well understood how obesity promotes BAT dysfunction, especially at the molecular level. Here we show that the transcription regulator TRIP-Br2 mediates ER stress-induced inhibiti...

TANK-binding kinase 1 (TBK1) plays an essential role in Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I)-mediated induction of type I interferon (IFN; IFN-α/β) and host antiviral responses. How TBK1 activity is negatively regulated remains largely unknown. We report that TNF receptor-associated factor (TRAF)-interacting protein (TRIP) promotes proteasomal degradation of TBK1...