21 Mammalian orthoreovirus (MRV) infection induces phosphorylation of translation initiation 22 factor eIF2α which promotes formation of discrete cytoplasmic inclusions, termed stress 23 granules (SGs). SGs are emerging as a component of the innate immune response to virus 24 infection, and modulation of SG assembly is a common mechanism employed by viruses to 25 counter this antiviral response...

The purpose of this paper is to examine factors driving developers to consider software factories and to scrutinize challenges to employing this methodology. The greatest attraction of the software factory approach is its logically sound conceptual framework covering the whole development process, from beginning to end. The greatest challenge to the successful utilization of this approach is it...

At existing and planned neutrino factories (high energy and high intensity neutrino beam facilities) precision studies of QCD in neutrino-nucleon interactions are a realistic opportunity. We investigate charmonium production in fixed target neutrino experiments. We find that J/ψ production in neutrinonucleon collision is dominated by the color octet S1 NRQCD matrix element in a neutral current ...

Software factory technology and practice -In the USA has recently accelerated rapidly with the boom in the CASE (Computer Aided Software Engineering) market. Concerns about long-range international competitiveness caused most large USA corporations to focus on corporate restructuring to achieve leaner, more adaptive modes of operation. Concerns with Federal deficits caused similar pressures on ...

Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus replication cycle [1]. Recently, advanced imagin...

We review recent progress at the two e + e − B factories. The first measurement of CP violation and the prospects for measuring all the angles of the unitarity triangle are discussed.

special issue focusses on the theme of metabolic engineering and the design of cellular factories. This is a very timely issue given that we sit at a newly developing nexus between systems biology understanding and synthetic biology design and construction [1]. The tangible result of these forces is a newfound capacity to rapidly produce an expanding array of new molecules in recombinant organi...

In the current economic climate, for many businesses it is generally no longer sufficient to pursue exclusively economic interests. Instead, integrating ecological and social goals into the corporate targets is becoming ever more important. However, the holistic integration of these new goals is missing from current factory planning approaches. This article describes the conceptual framework fo...

The rapid increase in the number of diabetic patients globally and exploration of alternate insulin delivery methods such as inhalation or oral route that rely on higher doses, is bound to escalate the demand for recombinant insulin in near future. Current manufacturing technologies would be unable to meet the growing demand of affordable insulin due to limitation in production capacity and hig...

In spite of many recent advances in MEMS technologies for integrated planar devices, most products of the future will continue to require assembly from separate parts because of differing material property requirements, the need to have a three-dimensional extent, or because of many different end user functional needs. Because many products will be very small and complex, or larger products wil...