BACKGROUND & OBJECTIVES Acquired and genetic thrombotic conditions, both organ and non organ specific, are associated with increased foetal wastage. This study was carried out to examine the placenta from women with abnormal pregnancies and a history of unexplained foetal loss, and to associate with maternal thrombophilia status. METHODS Placentas from eight women with history of unexplained ...

Inherited thrombophilia is a genetically determined tendency to thrombosis. In 1965 the first family with antithrombin deficiency was described, and for many years this was the only identifiable cause of thrombophilia. More recently, pedigree and case–control studies have confirmed that the risk of venous thrombosis is increased by deficiencies of antithrombin, protein C, and protein S, and by ...

The utility of laboratory investigation of relatives of individuals with inherited thrombophilia is uncertain. To assess the risk of venous thromboembolism (VTE) among the carriers, we investigated a family cohort of 1,720 relatives of probands with thrombophilia who were evaluated because of VTE (n=1,088), premature arterial thrombosis (n=113), obstetric complication (n=257), or universal scre...

TOPIC: Critical Care TYPE: Original Investigations PURPOSE: There is increased evidence suggests that inherited thrombophilia associated with higher risk of arterial thromboembolism, such as myocardial infarction and ischemic stroke. The previous study showed no association between out-of-hospital cardiac arrest. We aim to investigate the outcomes after in-hospital arrest (IHCA). METHODS: A ret...

In the past decades, the recognition of several inherited thrombophilic traits has greatly improved our knowledge of the pathogenesis of venous thromboembolism, explaining about half of all idiopathic cases. As a consequence, thrombophilia testing has enormously increased in the past years for various clinical conditions. In this paper, the current indications of the most commonly tested thromb...

Although hypercoagulable states are most often associated with venous thromboses, arterial thromboses are reported in protein C, protein S, antithrombin deficient patients and in those with factor V Leiden, components of hereditary thrombophilia. Because these arterial thromboses (peripheral artery disease, myocardial infarction, and cerebral infarction) mostly affect young persons, aged below ...

UNLABELLED In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid-antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithrombin deficiency, hyperhomocysteinemia and also with factor V Leiden, prothro...

Inherited risk factors for vascular disease include factor V Leiden [1], prothrombin [2] and methylenetetrahydrofolate reductase (MTHFR) point mutations [3]. The use of oral contraceptives is also a recognized risk factor for venous thromboembolism [4]. In Eastern Mediterranean countries, the highest frequency of factor V Leiden was reported in Lebanon (14%) [5,6]. However, there are no studies...