It is suspected that environmental exposure to non-syndromic oral clefts, which includes cleft lip (CL), and palate (CLP) has an effect on epigenetic mechanisms, particularly deoxyribonucleic acid (DNA) methylation. DNA methylation will be expressed during facial morphogenesis have impact development. This study aimed observe differences in between CL CLP, mothers CLP mothers, correlation mothe...

Background Tooth abnormalities are most often present in individuals with oral clefts than general population, and lead to a long-term impact on facial anatomy and self-esteem. The purpose of this study was to compare the proportion of dental anomalies between the cleft side and non-cleft side in individuals with non-syndromic unilateral alveolar clefts (AC). Material and Methods Twenty cone ...

Orofacial clefts, including cleft lip with or without cleft palate, are among the most common visible birth defects, occurring in 1 of every 500 – 1000 live births worldwide ( Murray, 1995 ). With a prevalence of 14.7 per 10 000 births in Australia ( Lancaster and Pedisich, 1995 ), orofacial clefts are the most frequent congenital craniofacial deformities ( Sinko et al. , 2005 ). Cleft lip and...

A large, population-based case-control study of facial clefts was carried out in Norway between 1996 and 2001. The study included 573 cases -- 377 with cleft lip with or without cleft palate and 196 with cleft palate only -- and 763 randomly selected controls. Maternal consumption of coffee and other caffeine-containing beverages in early pregnancy was recorded shortly after birth. Compared wit...

Defects such as cleft lip with or without cleft palate (CL/P) are among the most common craniofacial birth defects in humans. In many cases, the underlying molecular and cellular mechanisms that result in these debilitating anomalies remain largely unknown. Perturbed hedgehog (HH) signalling plays a major role in craniofacial development, and mutations in a number of pathway constituents underl...

OBJECTIVE The purpose of this article was to review the published literature on 3-dimensional ultrasound (3DUS) and 4-dimensional ultrasound (4DUS) in obstetrics and determine whether 3DUS adds diagnostic information to what is currently provided by 2-dimensional ultrasound (2DUS) and, if so, in what areas. METHODS A PubMed search was conducted for articles reporting on the use of 3DUS or 4DU...

DESCRIPTION A 32-year-old woman, 22 weeks pregnant of monochorionic diamniotic twins, underwent fetoscopic laser coagulation of placental vascular anastomoses for a twin-to-twin transfusion syndrome (TTTS) Quintero stage III. Preoperative twoand three-dimensional ultrasound revealed the presence of an isolated unilateral cleft lip in the recipient twin (figure 1). At the time of surgery, fetosc...

Children with orofacial clefts are believed to have distinctly elevated risk for a variety of adverse social-emotional outcomes including behavior problems, poor self-concept, and parent-child relationship difficulties. This assumption has been based primarily on theories of facial appearance and social bias, a handful of empirical studies, and clinical impressions. Studies of these children ha...

BACKGROUND This report documents the authors' experience with 95 hypertelorism corrections performed since 1971. The authors note their findings regarding outcomes, preferred age at surgery, technique, and stability of results with growth. METHODS Patients were classified into three groups: midline clefts (with or without nasal anomalies, Tessier 0 to 14); paramedian clefts (symmetric or asym...