References: l)Nussbaum,R.L., Airhart,S.D. and Ledbetter.D.H. (1986) Am. J. Med. Genet. 23, 457-466. 2)Patterson,M.N., Bell,M.V., BloomfieldJ,, Flint,T., Dorkins.H., Thibodeau.S.N., Schaid,D., Bren,G., Schwartz,C.E., Wieringa,B., Ropers,H.-H., Callen.D.F., Sutherland.G., Froster-Iskenius.U., Vissing.H. and Davies,K.E. (1989) Genomics 4, 570-578. A Taql polymorphism adjacent to the factor VIII ge...

Meistera chinensis is one of the new generations Zingiberaceae family. have a large number species and still need research to reveal their chemical content. chinensis, local plant that widespread in Konawe Regency, Southeast Sulawesi. Empirically, M. used as flavor enhancer food, aches, increases body immunity. There are no reports content or its biological activity. In this study, fruit was te...

PURPOSE To describe the clinical and genetic findings in one Chinese family with autosomal recessive retinitis pigmentosa (arRP) and in three unrelated Chinese families with Usher syndrome type II (USH2). METHODS One family (FR1) with arRP and three unrelated families (F6, F7, and F8) with Usher syndrome (USH), including eight affected members and seven unaffected family individuals were exam...

ABSTRACT: The foremost intention of present research was the preparation and assessment mouth dissolving formulation Rivaroxaban its validation. During work, this tablet formulated by straight compression technique means Cros-carmellose sodium Sodium starch glycolate as super-disintegrants (concentration 2, 4, 6%) Avicel 102 a binder. preparations were exposed to different consideration paramet...

Gene therapy is an attractive approach for the treatment of hemophilia, as continuous expression of donated clotting factor VIII (FVIII) DNA would ensure clotting factor replacement at constant circulating levels rather than at the peaks and troughs that characterize the current protein infusion therapeutic approach. In this issue of the JCI, Shi et al. describe an interesting variant of a gene...

The human F8/G253 antigen, B-CAM, is a cell surface glycoprotein that is expressed with restricted distribution pattern in normal fetal and adult tissues, and is up-regulated following malignant transformation in some cell types. We have isolated a complementary DNA for B-CAM using an expression cloning technique. The complementary DNA (EMBL accession number X80026) encodes a 588-amino acid pro...

UNLABELLED Severity of bleeding phenotype in hemophilia A (HA) depends on the underlying mutation in the F8 gene and, ultimately, on the concentration and functional integrity of the factor VIII (FVIII) protein in circulating plasma. Initial diagnosis for HA and monitoring of treatment is typically performed by measuring of FVIII activity by either one-stage assay or chromogenic assay. We revie...

We determine the η−η mixing angle via a procedure relatively independent of theoretical assumptions by simultaneously fitting η, η reactions involving the anomaly— η, η → γγ, π+π−γ. We extract reasonably precise renormalized values of the octet and singlet pseudoscalar decay constants F8, F0, as well as the mixing angle θ. * Research supported in part by the National Science Foundation