These results clearly point out that p53 uses a hyThe p53 gene and its protein product have become the drophobic interface in its N-terminal domain to interact center of intensive study ever since it became clear with the transcriptional machinery of the cell and its that slightly more than 50% of human cancers contain negative regulators. Recently, the N-terminal domain of mutations in this ge...

INTRODUCTION Providing comprehensive services for about 400 patients in the South Herefordshire area, the community mental health team manages cases of varying severity and complexity, ranging from Schizophrenia, to neuroses and disorders of adult personality. Antipsychotic medication remains a mainstay of treatment and management for patients under the team case load; hence a need exists for a...

The new anti-neutron, first proposed in 2011 [16], and ordinary neutrons, are both without electric charge, and are therefore rather difficult to accelerate and/or impact together in a high energy collider sufficient to cause annihilation, and thus create a 100% energy “Higgs” styled Boson, such Bosons arguably representing all of the mass in the universe. This very high energy impact combinati...

-The formation ofhydroxy-Al-interlayered montmorillonite was affected by complexing organic acids. Montmorillonite (<2.0 t~m) was aged for three months at an initial pH of 5.0 or 6.0 in A1C13 solutions containing citric or tannic acid at organic acid/A1 molar ratios from 0 to 1.0. The A1/clay ratio in the system was 900 meq AP+/100 g of montmorillonite. Ion-exchange experiments revealed that or...

TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentiall...

This paper focuses on the factors which influence collaborative learning in distance education. Distance education has been around for many years and the use of collaborative learning techniques in distance education is becoming increasingly popular. Several studies have demonstrated the superiority of collaborative learning over traditional modes of learning and it has been identified as a pot...

We previously showed that (a) estrogen-related receptor A1 (ERRA1) down-modulates estrogen receptor (ER)–stimulated transcription in low ErbB2–expressing MCF-7 mammary carcinoma cells, and (b) ERRA and ErbB2 mRNA levels positively correlate in clinical breast tumors. We show here that ERRA1 represses ERA-mediated activation in MCF-7 cells because it failed to recruit the coactivator glucocortic...

Ocean Drilling Program (ODP) Leg 199, “The Paleogene Equatorial Transect” (Sites 1215 through 1222), was designed to study the evolution of the equatorial Pacific current and wind system as the Earth went from maximum Cenozoic warmth to initial Antarctic glaciations. The drilling program was primarily devoted to a transect along 56to 57-Ma crust, old enough to capture the Paleocene/ Eocene boun...