The ATPase activity of rat liver Fl is inhibited by a number of covalent labeling agents which are reported to have preferential specificities for either tyrosine, carboxyl, or amino residues. Two types of agents, ie. trypsin and sulfhydryl reactive compounds, are without effect on the ATPase activity of F1. In this study, the effect of trypsin on energy-linked functions catalyzed by the mitoch...

Hypertension and stroke in spontaneously hypertensive rats (SHR) were investigated genetically using stroke-prone SHR (A3), stroke-resistant SHR (C) and their hybrids, hybrid of A3 and C (F1), offspring of F1 X F1 (F2), and those of backcrossing of F1 to the respective parental strains, BC(F1 X A3) and BC(F1 X C). The average blood pressure measured without anesthesia increased in the following...

The purpose of this study was to estimate correlations between purebred and F1 crossbred performance to verify the appropriateness of current models used in multibreed selection. Records on birth weight (WB) and weaning weight (WW) from purebred Limousins (LIM) and Limousin × Angus progeny (F1) were used to estimate genetic parameters using a multiple-trait (purebred and F1 weights were differe...

Information was sought on whether B cells undergo abnormal differentiation in F1 leads to parent chimeras (irradiated parental-strain mice reconstituted with F1-hybrid bone marrow cells). As assessed by collaborative responses to sheep erythrocytes in vivo, three different types of T cells restricted to interaction with strain a H-2 determinants were shown to collaborate as effectively with het...

We have investigated the pathway of prothrombin activation in blood and plasma. By means of a rapid purification procedure involving chromatography on DEAE-cellulose and hydroxyapatite, we demonstrated that the major prothrombin fragment in serum is that representing the amino-terminal half of prothrombin (i.e. F1-2). The F1-2 isolated was characterized by its size, amino acid and antigenic com...

Haldane's Rule and Darwin's Corollary to Haldane's Rule are the observations that heterogametic F1 hybrids are frequently less fit than their homogametic siblings, and that asymmetric results are often obtained from reciprocal hybrid crosses. In Caenorhabditis, Haldane's Rule and Darwin's Corollary have been observed in several hybrid crosses, including crosses of Caenorhabditis briggsae and C....

We define and study the category Rep(Q, F1) of representations of a quiver in Vect(F1) the category of vector spaces ”over F1”. Rep(Q, F1) is an F1–linear category possessing kernels, co-kernels, and direct sums. Moreover, Rep(Q, F1) satisfies analogues of the Jordan-Hölder and Krull-Schmidt theorems. We are thus able to define the Hall algebra HQ of Rep(Q, F1), which behaves in some ways like ...

Given two maps f1, f2 : M −→ N between manifolds of the indicated arbitrary dimensions, when can they be deformed away from one another? More generally: what is the minimum number MCC(f1, f2) of pathcomponents of the coincidence space of maps f ′ 1 , f ′ 2 where f ′ i is homotopic to fi, i = 1, 2 ? Approaching this question via normal bordism theory we define a lower bound N(f1, f2) which gener...

The role of immunity to intracellular Ags in resistance to infection by Yersinia is not well established. The enteropathogenic bacteria Yersinia pseudotuberculosis and Yersinia enterocolitica actively translocate Ags to the cytosol of eukaryotic cells. Whereas Yersinia pestis does not always express the requisite cellular adhesins, results have varied as to whether similar cytosolic translocati...