The effects of gentamicin, lithium and combination of these drugs on ultrastructural morphology of rat submandibular glands were studied. Daily intraperitoneal injection of 40 mg/kg of gentamicin which causes chronic salivary gland toxicity, led to a marked decrease in gland's dry weight and total protein concentration but did not affect DNA content. Electron micrograph (EM) of submandibular ...

background: despite significant reduction in global disease prevalence, leprosy still has a high rate of disability while its determinants are unfair and many of them are amendable. the objective of this study was to measure inequality of disability in leprosy in iran. methods: this was a cross‑sectional study (2006‑2007) on all living people affected by leprosy registered in w. azerbaijan prov...

attention-deficit/hyperactivity disorder (adhd) is a highly heritable neuropsychiatric disorder associated with significant impairments in occu pational, academic, neuropsychological, and social functioning. central nervous system (cns) stimulants are recommended as first-line medication therapy for children. cns stimulants include formulations of methylphenidate and amphetamine derivatives and...

The treatment landscape of metastatic renal cell carcinoma (mRCC) dramatically changed with the introduction of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) [1]. Despite major advances in the field of immunotherapy, TKIs remain a fundamental therapy in mRCC. Novel methods to optimize VEGFR TKI delivery are thus critical to improve clinical outcomes while ...

We used decision-analysis modeling to compare costs and outcomes of clarithromycin extended-release (Biaxin XL, Abbott Laboratories, Abbott Park, Illinois, USA) and clarithromycin immediate-release (Biaxin, Abbott Laboratories, Abbott Park, Illinois, USA) for outpatients with lower respiratory tract infections (LRTI). More patients achieved clinical cure with extended-release (83.9%) versus imm...

Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as lymphoproliferative diseases (LPDs) and multiple myeloma. In these malignanci...