This study was performed to assess the prevalence and genotypes of plasmid-borne extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in Escherichia coli in Korea. A total of 576 isolates of E. coli was collected from 12 Korean hospitals during May and July 2007. A phenotypic confirmatory test detected ESBLs in 82 (14.2 %) of the 576 E. coli isolates. The most common types of ESBL...

conclusions our study showed high esbl incidence, with ctx-m genotype as the emerging strain in our hospitals. high co-resistance to other non-β-lactam antibiotics is a major challenge for the management of esbl infections. results the esbls were found in (62.89%) of e. coli and (67.5%) of k. pneumoniae isolates. the majority of the typeable isolates harbored two or more esbl genes (73%). overa...

To determine the prevalence and genotypes of extended-spectrum beta-lactamases (ESBLs) among clinical isolates of Klebsiella pneumoniae and Escherichia coli, we performed antibiotic susceptibility testing, pI determination, induction testing, transconjugation, and DNA sequencing analysis. Among the 509 isolates collected from 13 university hospitals in Korea, 39.2% produced ESBLs. ESBL-producin...

background clinical significance of extended-spectrum beta-lactamases (esbls) production in enterobacter spp. has not well been established. objectives this study was conducted to investigate the prevalence of esbls produced by enterobacter spp. in clinical isolates. materials and methods this descriptive cross-sectional study was performed during may 2010 to april 2012 in the city of sanandaj,...

in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Pediatrics 2008; 121: 689–96. 3. Livermore DM, Canton R, Gniadkowski M et al. CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother 2007; 59: 165–74. 4. Bonacorsi S, Clermont O, Houdouin V et al. Molecular analysis and experimental virulence of French and North American ...

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is t...

Introduction Antibiotic resistance is a serious problem in clinical medicine [1]. Production of inactivating enzymes is one of the most common mechanisms by which different microorganisms can acquire resistance against several antimicrobial agents, especially βlactams. Extended spectrum β-lactamases (ESBLs) mediate resistance against different broad spectrum cephalosporins and monobactams [2]. ...

In November 1997, all Enterobacteriaceae isolated at 15 hospitals in Brooklyn were collected. Extended-spectrum beta-lactamases (ESBLs) were present in 44% of 409 Klebsiella pneumoniae isolates. Six isolates had reduced susceptibility to carbapenems, including two that were not susceptible to any of the antibiotics tested. Pulsed field gel electrophoresis revealed a commonality of resistant iso...

Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL pr...