Introduction The complex pharmacodynamic mechanism of topiramate is currently approved for only two major diseases: epilepsy, mono or combined therapy, and preventing episodes of migraine. However, there are many other studies that emphasize other potential clinical effects deriving from its complex action and leading to its use in acute nociceptive pain and neuropathic pain management. Topiram...

The present study investigated the effects of focusing attention towards auditory or somatosensory stimuli on perceptual sensitivity and response bias using a signal detection task. Participants (N = 44) performed an unspeeded detection task in which weak (individually calibrated) somatosensory or auditory stimuli were delivered. The focus of attention was manipulated by the presentation of a v...

Pain is the hallmark of patients with chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS). Despite numerous hypotheses, the etiology and pathogenesis remain unknown. To better understand CP/CPPS, we used a murine experimental autoimmune prostatitis model to examine the development, localization, and modulation of pelvic pain. Pelvic pain was detected 5 days after antigen instillati...

Introduction Key characteristics of musculoskeletal pain are (i) diffuse aching pain, (ii) referred pain to distant somatic structures, (iii) deep-tissue hyperalgesia (general and localized), (iv) transition from acute to chronic pain, and (v) disturbed muscle function with reduced contraction force. Methods for quantitative assessment of musculoskeletal pain characteristics provide clinically ...

Noninvasive cortical stimulation (NICS) can produce analgesic effects by means of repetitive transcranial magnetic stimulation or transcranial direct current stimulation (tDCS). Such effects have been demonstrated on chronic ongoing pain, as in acute provoked pain. The investigation of induced changes in the perception of experimental pain by NICS could help clinicians and researchers to better...