In clinical research, questionnaires are an important tool available for population and large family studies to gather information on a patient’s medical history. In 1989, we described a large kindred of FrenchCanadian descent with an 8-fold increased risk of venous thrombosis due to the 3363C insertion in the protein C gene [1]. We developed a questionnaire for use in this family to assess gen...

A new score statistic is derived, which uses information from registries (age-specific incidences) and family studies (sib-sib marginal correlation) to weight affected sibling pairs according to their age at onset. Age at onset of sibling pairs is modelled by a gamma frailty model. From this model we derive a bivariate survival function, which depends on the marginal survival and on the margina...

We conducted a tuberculosis contact investigation for a female military recruit with an unreported history of multidrug-resistant tuberculosis (MDRTB) and subsequent recurrence. Pertinent issues included identification of likely contacts from separate training phases, uncertainty on latent MDRTB infection treatment regimens and side effects, and subsequent dispersal of the contacts after exposure.

Introduction Conclusions References

In arterialized venous flaps (AVFs) the venous network is used to revascularize the flap. While the feasibility of AVFs in soft tissues has been reported there is no study on osseous AVFs. In this study we aim to assess the flap survival of osseous AVFs in a pig model. Medial femoral condyle flaps were elevated in 18 pigs. Three groups were created: AVF (n = 6), conventional arterial flap (cAF,...

Understanding and controlling the flowfield in and around a cavity has challenged researchers for a number of years. The presence of a cavity on a body has been observed to significantly increase the mean drag, cause flow-induced vibrations and give rise to strong acoustic production. Of particular interest here are the flow structure and dynamics associated with open shallow rectangular caviti...

This paper considers the problem of cooperative navigation and mapping by a heterogeneous team of multiple autonomous underwater vehicles (AUVs). We address a form of cooperative Simultaneous Localization and Mapping (SLAM) in which only one vehicle is responsible for maintaining estimates of the map and poses for each robot. By combining inter-vehicle measurements with observations of the envi...

The paper analyzes the e¤ects of more intense competition on …rms’incentives to invest in process innovations. We carry out experiments for two-stage games, where R&D investment choices are followed by product market competition. As predicted by theory, an increase in the number of …rms from two to four reduces investments. However, a positive e¤ect is observed for a switch from Cournot to Bert...

We explore the management of information and the response of market prices to such information. Sellers may be uncertain of dividends. We examine whether sellers anticipate buyers’ pricing behavior and whether buyers’ prices reflect correct inferences of the disclosure strategy of sellers. Buyers’ inferences and sellers’ anticipation require implicit Bayesian updating in solving for the equilib...