AIMS 2D speckle tracking echocardiography allows for assessment of left ventricular (LV) torsional deformation as a composite function of the radial, longitudinal and circumferential fibres. We test the hypothesis that post-exercise LV torsional dynamics are more sensitive markers for myocardial dysfunction than resting measures, and better predictors for exercise capacity compared to post-exer...

Ischemic heart disease (IHD) patients with a decreased exercise capacity have increased angina attack rate and poor quality of life (QOL). Conventional hemodynamic drugs show limited improvement in exercise performance. Therefore we need new drugs that may further improve exercise capacity. Trimetazidine (TMZ) exerts its anti-ischemic effect by reducing fatty acid oxidation and stimulating gluc...