نتایج جستجو برای: exemestane
تعداد نتایج: 576 فیلتر نتایج به سال:
Exemestane (EXE) is an aromatase inhibitor used for the prevention and treatment of breast cancer. The major metabolic pathway for EXE is reduction to form the active 17β-dihydro-EXE (17β-DHE) and subsequent glucuronidation to 17β-hydroxy-EXE-17-O-β-D-glucuronide (17β-DHE-Gluc) by UGT2B17. The aim of the present study was to determine the effects of UGT2B17 copy number variation on the levels o...
• Nonsteroidal, type II (reversible) anti-aromatases, termed aromatase inhibitors. The first clinically available drug, aminoglutethimide (AG), belongs to this class. Aminoglutethimide is nonspecific and requires patients to associate a corticosteroid. Two newer, more specific agents that are administered orally and act solely on aromatase have been tested: letrozole (Let) (2.5 mg/day) and anas...
S6-01. Finn RS, Crown JP, Lang I, et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/ TRIO-18): a randomised phase 2 study. Lancet Oncol. 2015;16(1):25-35. Turner NC, Ro J, André F, et al. Palbociclib in hormone-receptor-positive ...
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