UNLABELLED Data emerging from the past 10 years have consolidated the rationale for investigating the use of aspirin as a chemopreventive agent; however, the mechanisms leading to its anticancer effects are still being elucidated. We hypothesized that aspirin's chemopreventive actions may involve cell-cycle regulation through modulation of the levels or activity of cyclin A2/cyclin-dependent ki...

The hepatic distribution kinetics of salicylic acid was determined using a single-pass dual hepatic artery (HA) and portal vein (PV) perfused in situ rat liver preparation. Bolus doses of [14C]salicylic acid and of reference markers ([3H]-water and [14C]-sucrose) were injected in a random order into either the HA or PV and then, after an appropriate interval, into the alternate vessel. The hepa...

Salicylic acid (SA) is a phyto-hormone that regulates physiological and biological processes in plants and can be used to improve plant growth under different environmental conditions, including water stress. Thus, a field experiment as split plot factorial based on randomized complete blocks design with three replications was conducted in 2014 to investigate the effects of fertilizer and salic...

Deficiency of nitrogen may lead to decrease in yield and yield potential of crop plants. An experiment was done under glasshouse conditions in order to investigate nitrogen levels and salicylic acid interaction on some physiologic traits of borage (Borago officinials L.). In this experiment various levels of nitrogen (including; 27.5, 55, 110, 220 and 330 mg/L from ammonium nitrate) and salicyl...

Catharanthus roseus L. is an important medicinal plant producing several terpenoid indole alkaloids (TIAs) such as vincristine and vinblastine secondary metabolites with anticancer activity. The TIAs biosynthetic pathways are affected by biotic and abiotic stresses. In this study the effect of drought (7 days), salinity (150 mM NaCl), foliar spray of salicylic acid (10-5 M) and salicylic acid i...

Salicylic acid (SA) is a phyto-hormone that regulates physiological and biological processes in plants and can be used to improve plant growth under different environmental conditions, including water stress. Thus, a field experiment as split plot factorial based on randomized complete blocks design with three replications was conducted in 2014 to investigate the effects of fertilizer and salic...