CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells and is associated with poor prognosis clinically, but its exact contributions to tumorigenesis are uncertain. In this study, we showed that genetic deficiency of CD98hc...

An approach to analyzing structures by using beam elements is developed with adaptive displacement interpolation functions. First, the element stiffness matrix and equivalent nodal loads are derived on the basis of the equilibrium between nodal forces and section forces rather than the compatibility between nodal deformations and section deformations, which avoids discretization errors caused b...

CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells and is associated with poor prognosis clinically, but its exact contributions to tumorigenesis are uncertain. In this study, we showed that genetic deficiency of CD98hc...

This paper deals with a class of parallel mechanisms, called Gough-Stewart platforms. For these mechanisms, pre-loaded by driving forces, the stiffness matrix is derived and its basic properties are established. It is shown when the stiffness matrix becomes asymmetric, how the parametric imbalance may influence the system stability, and how the center of stiffness depends on the force pre-loadi...

This paper describes a stiffness analysis of a 6-RSS parallel manipulator by using matrix structural analysis. The stiffness analysis is based on standard concepts of static elastic deformations. The formulation has been implemented in order to obtain the stiffness matrix that can be numerically computed by defining a suitable model of the manipulator, which takes into account the stiffness pro...

This paper studied the stiffness model and characteristics of a planar 3-RPS PM with 3-DOF. The 6 × 6 form stiffness matrix of the planar 3-RPS PM is derived with both active and constrained wrenches considered. To characteristic the stiffness of the planer 3-RPS PM, two decomposition methods including the eigenscrew decomposition and the principle axes decomposition are applied to the stiffnes...

This paper investigates the synthesis of a spatial stiffness matrix using simple line springs. A new algorithm is developed, which enables the selection of constituent springs based on their positions and directions. The constraining space of the line springs is then investigated. It is shown that an isotropic stiffness matrix, in general, can be split into the sum of two rank-3 stiffness matri...

At present time, the spectral dynamic stiffness method is being actively developed as an alternative to finite element for vibration and stability problems of composite structures from beams, rods, plates shells. This approach, based on exact solutions governing differential equations, makes it possible more effectively study problem in medium high frequency ranges, gives analytical expressions...

One step on the way to approach human performance in robotics is to provide joint torque sensing and control for better interaction capabilities with the environment, and a large number of actuated degrees of freedom (DOF) for improved versatility. However, the increasing complexity also raises the question of how to resolve the kinematic redundancy which is a direct consequence of the large nu...