BACKGROUND The early warning score (EWS) was developed to identify deteriorating patients early. It is a track-and-trigger system based on vital signs designed to direct appropriate clinical responses based on the seriousness and nature of the underlying condition. Despite its wide dissemination, serious adverse events still occur, often due to failure among staff on general wards to follow the...

Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of epigenetic mechanisms in this process, focusing on Ewing sarcoma cells that are dependent on the EWS-FLI1 fusion protein. We established reference epigenome maps comprising DNA methylation, seven histone marks, o...

PURPOSE Clear cell sarcoma (CCS) usually arises in the lower extremities of young adults and is typically associated with a t(12;22) translocation resulting in the fusion of EWS (EWSR1) with ATF1, a gene encoding a member of the cyclic AMP-responsive element binding protein (CREB) family of transcription factors. CCS arising in the gastrointestinal tract is rare and its pathologic and molecular...

Common variants in APOA5 and APOC3 have been associated with differences in plasma triglyceride (TG) levels in healthy individuals. The aim of this study was to examine the association of APOA5 (-1131T>C, S19W) and APOC3 (-482C>T, 1100C>T) polymorphisms in patients with type 2 diabetes (T2D) of European White (EW) (n=931), Indian Asian (IA) (n=610) and Afro-Caribbean (AC) (n=167) origin, with l...

Nuclear receptors represent a large family of transcription factors involved in development, differentiation, homeostasis, and cancer. In recent years, a growing number of cofactors has been discovered that participate in the regulation of the transcriptional activity of these proteins. We present in this study the identification of a cofactor, the homeotic protein Six3, which differentially re...

Summary The performance of an in-house protocol for virus detection on commercialized electrostatic wipes (EWs) was assessed experimentally by impregnating them with suspensions cytomegalovirus, adenovirus, and influenza virus, determining the recovery efficiency, repeatability, limit protocol. sensitive enough to detect 4 log10 gene copies virus. At room temperature, RNA stable EWs at least fo...

Suppression of the expression of antiangiogenic factors has been closely associated with multiple malignancies. Thrombospondins 1 and 2 are members of a family of angiogenic inhibitors that are regulated by several oncogenes. In this study, we investigate the role of thrombospondins in Ewing's sarcoma and their regulation by EWS/ETS fusion oncoproteins. We show that the EWS/FLI1 fusion suppress...

A new class of entanglement witnesses (EWs) called reduction type entanglement witnesses is introduced, which can detect some multi-qudit entangeled states including PPT ones with Hilbert space of dimension d1 ⊗ d2 ⊗ ... ⊗ dn . The novelty of this work comes from the fact that the feasible regions turn out to be convex polygons, hence the manipulation of these EWs reduces to linear programming ...

One of the biggest problems of SMEs is their tendencies to financial distress because of insufficient finance background. In this study, an early warning system (EWS) model based on data mining for financial risk detection is presented. CHAID algorithm has been used for development of the EWS. Developed EWS can be served like a tailor made financial advisor in decision making process of the fir...

Early warning score (EWS) is an approach to detect the deterioration of a patient. It is based on a fact that there are several changes in the physiological parameters prior a clinical deterioration of a patient. Currently, EWS procedure is mostly used for in-hospital clinical cases and is performed in a manual paper-based fashion. In this paper, we propose an automated EWS health monitoring sy...