BACKGROUND AND PURPOSE Functional correlates of microstructural damage of the brain affected by MS are incompletely understood. The purpose of this study was to evaluate correlations of visual-evoked potentials with microstructural brain changes as determined by DTI in patients with demyelinating central nervous disease. MATERIALS AND METHODS Sixty-one patients with clinically isolated syndro...

OBJECTIVE This study examined morphological changes in the cortical auditory evoked potential (CAEP) waveform as a function of varying stimulation rate. Stimuli were presented in a paradigm which indirectly assesses the refractory properties of the underlying neuronal generators. METHODS CAEPs were recorded in 50 normal-hearing children (3-12 years) and 10 young adults (24-26 years). A speech...

Considerable evidence exists for developmental changes in latency and amplitude of the auditory evoked potential termed N100. However, it is widely recognized that the N100 wave comprises multiple, temporally overlapping neural generators, and few data are available addressing either individual generator development or mechanisms behind such change. Using magnetoencelphalographic (MEG) measurem...

Averaging single trial evoked potential data to produce an estimate of the underlying signal obscures trial-to-trial variation in the response. We describe a method for estimating slow changes in the evoked potential signal by smoothing the data over trials. We discuss the crucial issue of deciding how much to smooth and suggest that an appropriate smoothing parameter is one that minimizes the ...

Attention filters and weights sensory information according to behavioral demands. Stimulus-related neural responses are increased for the attended stimulus. Does alpha-band activity mediate this effect and is it restricted to conscious sensory events (suprathreshold), or does it also extend to unconscious stimuli (subthreshold)? To address these questions, we recorded EEG in healthy male and f...

Mismatch negativity (MMN) was measured on normal-hearing young adult women and men to determine the effect of gender on this auditory evoked potential (AEP). In the experimental condition, recordings were obtained for 1000-Hz tone bursts presented at 75 dB nHL (standard stimuli) and 60 dB nHL (deviant stimuli). AEPs also were obtained in a control condition in which all stimuli were presented a...

Many researchers have investigated the possibility of using auditory evoked potentials (AEPs) to objectively diagnose tinnitus. Published AEP studies suggest differences in neural activity in individuals with tinnitus compared to control groups, but the results are not consistent. There is a great deal of variability seen in auditory evoked- and event-related potentials in the tinnitus populati...