In order to study the epidemiology of trichinellosis with special emphasis on swine a detailed study was performed. The goals of the study were to define the prevalence of trichinellosis in swine and rats and to determine the etiological agents of the disease with special emphasis on sylvatic species, Trichinella britovi. Considering the obtained data it can be concluded that the risk of Trichi...

Oral submucous fibrosis (OSF) is now accepted globally as an Indian disease, having highest malignant potential than any other oral premalignant lesions. The understanding of the exact role of alkaloids and other etiological agents with respect to pathogenesis will help the management and minimize the blind clinical trials and treatment modalities. This article provides an overview of the etiop...

Etiology Increased frequency in family members of patients with primary biliary cirrhosis (PBC) suggests that there are genetically determined susceptibility factors. Several etiological factors, including infectious agents, environmental toxins or drugs, and abnormal or toxic bile acids, have been suggested as having putative roles in the development of PBC. Similar to other presumed autoimmun...

Background. A third wave of COVID-19 infection is now sweeping across the globe. Severe injury epithelial barrier, caused by action respiratory viruses (including coronaviruses), facilitates invasion tract with other germs, like viruses, fungy or bscteria. Methods. 92 inpatients pneumonia and 68 nosocomial (NP) non were enrolled in our study. For microbiological assessment sputum samples collec...

Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young children worldwide. These nonenveloped viruses enter cells using different types of endocytosis and, depending on the virus strain, travel to different endosomal compartments before exiting to the cytosolic space. In this Gem, we review the viral and cellular factors involved in the different stages of ...

Currently, no pharmaceuticals for the etiological treatment of degenerative protein-misfolding diseases (e.g., ALS, Alzheimer's or prion diseases) are commercially available. In this technical note theoretical considerations and practical approaches concerning the development of chaperone-based medications from medicinal plants (e.g., Ginkgo biloba) are reviewed and discussed in detail. Phytoch...

Currently, no pharmaceuticals for the etiological treatment of degenerative proteinmisfolding diseases (e.g., ALS, Alzheimer’s or prion diseases) are commercially available. Therefore, in this technical note theoretical considerations and practical approaches concerning the development of chaperone-based medications from medicinal plants (e.g., Ginkgo biloba) are reviewed and discussed in detai...

The following aspects are described for each of the main bacterial diseases in which vaccination is employed: (i) the biochemical, antigenic and genetic heterogeneity of the etiological agents; (ii) their geographical distribution and host range; (iii) the effectiveness and problems of current commercial vaccines; and (iv) the new vaccination approaches using recombinant DNA technology or other...

In this study, nested PCR using novel primers targeting the pan-dermatophyte-specific sequence of the chitin synthase 1 gene (CHS1) was compared with KOH microscopy, culture isolation, and single-round PCR for diagnosis of 152 patients with clinically suspected onychomycosis. Results indicate that nested PCR may be considered the gold standard for the diagnosis of cases of onychomycosis for whi...